Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases
Abstract
:1. Introduction
2. Beyond Cancers: Additional Pathologies Associated with TWIST1
3. TWIST1, EMT, and Cancer Stem Cell Phenotypes
4. TWIST1, EMT, and Drug Response in Cancer
4.1. Overview
4.2. EMT and Cytotoxic Drugs
4.3. Regulation of EMT Protein Expression
4.4. EMT and Multi-Drug Resistance
4.5. EMT and Response to Anti-Angiogenic Therapy
4.6. EMT and Response to Growth Factor Inhibition
4.7. EMT and Ferroptosis
4.8. EMT and Drug Sensitivity
4.9. Intersection of CSC and Drug-Resistant Phenotypes
Drug | Cancers | Genes/Pathways Impacted | References |
---|---|---|---|
Cisplatin | Ovarian *, mesothelioma, gastric, NSCLC, breast | Akt, miRNA, Rab31, eIF5A2, CDK1 | [85,86,88,89,90,93,97,98,103] |
Oxaliplatin | CRC | Akt, MFAP2, HK2, FHL3, Slug | [87,94,104,107] |
5-Fluorouracil | CRC | Akt | [87] |
Paclitaxel | Breast, ovarian | Akt2, CDK1 | [86,91,103] |
Resveratrol | Ovarian | Akt, hedgehog | [90] |
Pterostilbene | Ovarian | STAT3 | [91] |
Doxorubicin | HCC | eIF5A2 | [96] |
Decitabine | AML | OGT | [105] |
Pazopanib | Renal | Vascular mimicry, androgen receptor | [112] |
Apatinib | Gastric | VEGFR2, COL1A2 | [114] |
Erlotinib | NSCLC | EGFR, Akt, MAPK | [115] |
Gefitinib | NSCLC | EGFR, Akt, non-coding RNA, microRNA | [116,117] |
Erastin | Gastric | CPEB1, ferroptosis | [118] |
Olaparib | Ovarian * | HR | [119] |
Nu-7441 | Ovarian * | HR | [119] |
ABT-888 | Breast * | HR | [121] |
Ophiobolin A | Breast * | EMT | [122] |
Milademetan | Intimal sarcoma * | MDM2/p53 | [123] |
Irenotecan | CRC | CSC | [124] |
Eribulin mesylate | Breast | Circulating tumor cells, CSCs | [125] |
Multiple | HCC, CRC, gastric | MDR1 | [108,109,110] |
5. TWIST1 and EMT as Therapeutic Targets
5.1. Overview
5.2. Drugs Targeting EMT
5.3. Gene Knockdown and Nanoparticle Approaches
5.4. Existing Drugs with Effects against EMT
Drug/Approach | Cancers | Pathways Impacted | References |
---|---|---|---|
COM33 | Ovarian | Migration, invasion, resistance | [130] |
Nisin | Liver | Frizzled | [131] |
α-Linolenic acid | Breast | TWIST1 turnover | [130] |
Ophiobin A | Breast | CSCs | [122] |
Harmine and derivatives | Breast, NSCLC (ulcerative colitis) | Invasion, TWIST1 turnover, DNA intercalation, CSCs | [53,133,134,135,136,137,138] |
Gene knockdown | Ovarian, breast, melanoma | DCLK1, TWIST1 | [143,144,145,146,147,148] |
BZ6 nanoparticles | Breast, pancreatic | Migration, TWIST1 | [149] |
Pirfenidone | Breast | TGFβ, Smad2 | [150] |
Metformin | Endometrial | TGFβ, ERK/MAPK | [151] |
Antrodia salmonea | Head and neck | HIF1α, glycolysis | [152] |
Formoterol | Lung | Reactive oxygen species (ROS) | [153] |
Aprepitant | Cervical, glioblastoma, breast, prostate | ROS, NFκB | [154,155,156,157] |
Paclitaxel nanoparticles | Breast | EMT and CSCs, mammospheres | [158] |
Entinostat | Gastric | Histone deacetylase, SALL4 | [159] |
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AML | acute myeloid leukemia |
AR | androgen receptor |
AS | antrodia salmonea |
CAFs | cancer-associated fibroblasts |
CPEB1 | cytoplasmic polyadenylation element binding protein 1 |
CRC | colorectal cancer |
CSCs | cancer stem cells |
DCLK1 | doublecortin-like kinase 1 |
EndMT | endothelial to mesenchymal transition |
EGFR | epidermal growth factor receptor |
EMT | epithelial-to-mesenchymal transition |
HCC | hepatocellular carcinoma |
HK2 | hexokinase-2 |
LPA | lysophosphatidic acid |
LSCs | leukemia stem cells |
MFAP2 | microfibrillar-associated protein 2 |
MMPs | matrix metallopeptidases |
NSCLC | non-small cell lung carcinoma |
OGT | O-GlcNAc transferase |
PDAC | pancreatic ductal adenocarcinoma |
PLK1 | polo-like kinase 1 |
PROTACs | proteolysis-targeting chimeras |
TGFβ | transforming growth factor beta |
TNBC | triple-negative breast cancer |
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Mirjat, D.; Kashif, M.; Roberts, C.M. Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases. Int. J. Mol. Sci. 2023, 24, 17539. https://doi.org/10.3390/ijms242417539
Mirjat D, Kashif M, Roberts CM. Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases. International Journal of Molecular Sciences. 2023; 24(24):17539. https://doi.org/10.3390/ijms242417539
Chicago/Turabian StyleMirjat, Dureali, Muhammad Kashif, and Cai M. Roberts. 2023. "Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases" International Journal of Molecular Sciences 24, no. 24: 17539. https://doi.org/10.3390/ijms242417539