Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
Abstract
:1. Introduction
2. Result and Discussion
2.1. Isolation of Compounds
2.2. Antioxidant Activity of Lignans
2.3. Anti-Inflammatory Activity
2.4. Gap Junction Intercellular Communication (GJIC)
3. Material and Methods
3.1. Plant Material
3.2. General Analytical Apparatus and Conditions
3.3. Extraction and Isolation
Isolation of Compound 1
3.4. Antiproliferative Activity
3.5. Cellular Antioxidant Activity (CAA) Assay
3.6. Detection of the Activation of NF-κB
3.7. The Scrape Loading-Dye Transfer (SLDT) Assay
3.8. Statistical Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Position | δH | δC |
---|---|---|
1 | - | 138.4 |
2 | 6.96, s | 140.3 |
3 | 2.15–2.26, m | 31.6 |
4 | - | 44.6 |
5 | - | 148.0 |
6 | 1.75–1.95, m | 30.9 |
7 | 2.29, m | 29.6 |
8 | 1.41–2.16, m | 25.4 |
9 | - | 36.7 |
10 | 1.80–1.96, m | 23.4 |
11 | 2.34–2.36, m | 39.0 |
12 | 0.91, s | 24.0 |
13 | 0.87, s | 22.1 |
14 | - | 175.0 |
15 | 4.41–4.84, d, J = 2.2 Hz | 110.0 |
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Rybnikář, M.; Malaník, M.; Šmejkal, K.; Švajdlenka, E.; Shpet, P.; Babica, P.; Dall’Acqua, S.; Smištík, O.; Jurček, O.; Treml, J. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. Int. J. Mol. Sci. 2024, 25, 3465. https://doi.org/10.3390/ijms25063465
Rybnikář M, Malaník M, Šmejkal K, Švajdlenka E, Shpet P, Babica P, Dall’Acqua S, Smištík O, Jurček O, Treml J. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International Journal of Molecular Sciences. 2024; 25(6):3465. https://doi.org/10.3390/ijms25063465
Chicago/Turabian StyleRybnikář, Michal, Milan Malaník, Karel Šmejkal, Emil Švajdlenka, Polina Shpet, Pavel Babica, Stefano Dall’Acqua, Ondřej Smištík, Ondřej Jurček, and Jakub Treml. 2024. "Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects" International Journal of Molecular Sciences 25, no. 6: 3465. https://doi.org/10.3390/ijms25063465