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Oxidative Stress and Inflammation in Chronic Diseases: What Can Nutrition Do?

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 3761

Special Issue Editors


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Guest Editor

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Guest Editor
Department of Medicine and Science of Aging, University “G. D’Annunzio”, 66100 Chieti, Italy
Interests: nutrition; oxidative stress; cellular biology; disease; antioxidant; bioactive vegetable; molecules; endogenous antioxidant enzymes; vegetable food; nitric oxide; inflammation diseases, inflammatory bowel disease
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Special Issue Information

Dear Colleagues,

We are pleased to announce that we are organizing a new Special Issue whose goal is to compile evidence on how nutrition strategies can regulate oxidative stress and inflammation. Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) in cells and tissue and the ability of a biological system to detoxify these reactive products. Uncontrolled oxidative stress can oxidize biomolecules or structurally modify proteins and genes to trigger signaling cascades that can lead to the onset and progression of inflammatory diseases.

Oxidative stress, inflammation and health or disease status are inter-related with each other and with nutrition. Dietary constituents with remarkably high antioxidant and anti-inflammatory capacity include many plant-derived antioxidant compounds, phytochemicals such as carotenoids, polyphenols and many others. Several of these constituents can interact with transcription factors related to anti-inflammatory and antioxidant effects. This Special Issue aims to explore antioxidants/foods containing polyphenolic antioxidants capable of interfering with the molecular signaling pathways activated by oxidative stress, as well as their possible roles in chronic inflammation-mediated disorders.

We invite authors to submit review articles and original research describing the possible nutritional approaches/bioactive natural molecules and innovative interventions in the management of oxidative stress and inflammation in chronic diseases.

We welcome original research articles and review articles.

Dr. Sara Franceschelli
Prof. Dr. Lorenza Speranza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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Research

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16 pages, 1681 KiB  
Article
Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
by Michal Rybnikář, Milan Malaník, Karel Šmejkal, Emil Švajdlenka, Polina Shpet, Pavel Babica, Stefano Dall’Acqua, Ondřej Smištík, Ondřej Jurček and Jakub Treml
Int. J. Mol. Sci. 2024, 25(6), 3465; https://doi.org/10.3390/ijms25063465 - 19 Mar 2024
Cited by 1 | Viewed by 1522
Abstract
Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect [...] Read more.
Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-κB activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (−)-gomisin N, (+)-γ-schisandrin, rubrisandrin A, and (−)-gomisin J. Full article
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Review

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19 pages, 1570 KiB  
Review
Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease
by Sara Jarmakiewicz-Czaja, Katarzyna Ferenc, Aneta Sokal-Dembowska and Rafał Filip
Int. J. Mol. Sci. 2024, 25(8), 4390; https://doi.org/10.3390/ijms25084390 - 16 Apr 2024
Cited by 2 | Viewed by 1365
Abstract
The problem of treating inflammatory bowel disease continues to be a topic of great interest for researchers. Despite the complexity surrounding their treatment and strategies to prolong periods of remission, there is a promising exploration of various compounds that have potential in combating [...] Read more.
The problem of treating inflammatory bowel disease continues to be a topic of great interest for researchers. Despite the complexity surrounding their treatment and strategies to prolong periods of remission, there is a promising exploration of various compounds that have potential in combating inflammation and alleviating symptoms. Selenium, calcium, magnesium, zinc, and iron are among these compounds, offering a glimpse of hope in the treatment of IBD. These essential minerals not only hold the promise of reducing inflammation in these diseases, but also show the potential to enhance immune function and possibly influence the balance of intestinal microflora. By potentially modulating the gut microbiota, they may help support overall immune health. Furthermore, these compounds could play a crucial role in mitigating inflammation and minimising complications in patients with IBD. Furthermore, the protective effect of these compounds against mucosal damage in IBD and the protective effect of calcium itself against osteoporosis in this group of patients are notable. Full article
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