5-(4-Bromophenyl)-7-(2,4-dimethoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine

Round 1

Reviewer 1 Report

Suwito and coworkers described the synthesis of a dihydrotetrazolo[1,5-a]pyrimidine derivative, although the authors described previously a similar paper for synthesis of another dihydrotetrazolo[1,5-a]pyrimidine derivative (Molvank, 2018, MPP(, DOI10.3390/M998). Therefore, this referee thinks that the present article to be published in Molbank, the authors should present something else such as biological activity, cytotoxic activity, …

Morover , there are some aspect of the article that the authors should correct:

-line 22, page 1, antiinflamation and antihepatitis.

-line 34, add a reference after pTSOH as catalyst.

-The figure 1 should be an called as Scheme 1. And the yields should appear and the numbers of the compounds.

-line 35, after reaction ad (Scheme 1).

-Explain the synthesis of compound 2, and explain that the compound is recrystalized.

-line 39, add a reference after published previously.

-In the experimental part , please add the mg, yield of compound 1 and 2.

-reference 10, the title of the article is in capital letters, please change.-

-Reference 12, the numbers of the molbank article is not 7-11, is M998. Please correct.

-Reference 13, which is the name of the journal? It should be written in italics

Author Response

Dear Reviewer,

herewith I send you the revised article following your advice and comments point by point as you see in the track changing mode.

Author Response File: Author Response.pdf

Reviewer 2 Report

  This manuscript contains a one pot synthesis of a dihydrotetrazolopyrimidine through cyclocondensation reaction between a chalcone derivative with 5-aminotetrazole. The background as well as the results are well presented and the authors take great care only to limit to assignment of the synthesized dihydrotetrazolopyrimidine based on FTIR, HRMS, 1D and 2D NMR spectroscopy.Thus, this manuscript could be interesting for the readers in this field of synthetic organic chemistry as well as pharmacological chemistry. Also this paper is easy to read and could well serve as the basis for a devel­opment of these field.

Comments

1.     In the text the authors described the previous reported synthesis of dihydrotetrazolopyrimidine (DHTPM) derivatives. The should pay some comments for the merits of the presently developed method in comparison with the reported methods.

2.    It is helpful for readers to indicate the compound numbers in Figures 1, 2 and Table 1.

3.    The spectral data for compound 2 in the text (page 2, line 46–55) should be moved to the experimental part (page 4, 3.3 Synthesis of Target Compound).

4.    In the experimental section melting point for compound 2 is required.

5.    The authors should improve the typos, hyphenation and capital letters (there are many)) in the text. 

I recommend this nice work for publication inmolbankafter minor revisions described above.

Author Response

dear Reviewer,

herewith I send you the revised manuscript following your advice and comments point by point as you can see in draft by track changing mode.

thank you very much,

best regards,

Hery suwito

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

I still believe that this article has very few interest if the authors dont do anything else, because the product is similar previos reports.