Next Article in Journal / Special Issue
Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu
Previous Article in Journal
Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus
Previous Article in Special Issue
An Ethanol Extract Derived from Bonnemaisonia hamifera Scavenges Ultraviolet B (UVB) Radiation-Induced Reactive Oxygen Species and Attenuates UVB-Induced Cell Damage in Human Keratinocytes
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2013, 11(1), 1-19; doi:10.3390/md11010001

Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions

1
Department of Marine Biology and Ecology, University of Gdansk, Al. Marszałka Piłsudskiego 46, Gdynia 81-378, Poland
2
Faculty of Fisheries, Istanbul University, Ordu Cad. No. 200, 34470 Laleli, Istanbul, Turkey
3
Department of Biosciences, Abo Akademi University, Tykistökatu 6A, Turku 20520, Finland
*
Author to whom correspondence should be addressed.
Received: 12 October 2012 / Revised: 13 November 2012 / Accepted: 11 December 2012 / Published: 21 December 2012
(This article belongs to the Special Issue Marine Algae)
View Full-Text   |   Download PDF [1020 KB, uploaded 24 February 2015]   |  

Abstract

Cyanobacteria produce a great variety of non-ribosomal peptides. Among these compounds, both acute toxins and potential drug candidates have been reported. The profile of the peptides, as a stable and specific feature of an individual strain, can be used to discriminate cyanobacteria at sub-population levels. In our work, liquid chromatography-tandem mass spectrometry was used to elucidate the structures of non-ribosomal peptides produced by Nodularia spumigena from the Baltic Sea, the coastal waters of southern Australia and Lake Iznik in Turkey. In addition to known structures, 9 new congeners of spumigins, 4 aeruginosins and 12 anabaenopeptins (nodulapeptins) were identified. The production of aeruginosins by N. spumigena was revealed in this work for the first time. The isolates from the Baltic Sea appeared to be the richest source of the peptides; they also showed a higher diversity in peptide profiles. The Australian strains were characterized by similar peptide patterns, but distinct from those represented by the Baltic and Lake Iznik isolates. The results obtained with the application of the peptidomic approach were consistent with the published data on the genetic diversity of the Baltic and Australian populations. View Full-Text
Keywords: Nodularia spumigena; cyanobacteria; non-ribosomal peptides; chemotypes; LC-MS/MS Nodularia spumigena; cyanobacteria; non-ribosomal peptides; chemotypes; LC-MS/MS
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mazur-Marzec, H.; Kaczkowska, M.J.; Blaszczyk, A.; Akcaalan, R.; Spoof, L.; Meriluoto, J. Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions. Mar. Drugs 2013, 11, 1-19.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top