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Mar. Drugs 2017, 15(4), 91; doi:10.3390/md15040091

Preparation, Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles

1
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
2
Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing 100875, China
3
Taizhou Roosin Medical Co., Ltd., Taizhou 225300, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Paola Laurienzo and Anake Kijjoa
Received: 27 November 2016 / Revised: 12 March 2017 / Accepted: 20 March 2017 / Published: 11 April 2017
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

Alginate (Alg) is a renewable polymer with excellent hemostatic properties and biocapability and is widely used for hemostatic wound dressing. However, the swelling properties of alginate-based wound dressings need to be promoted to meet the requirements of wider application. Poly(γ-glutamic acid) (PGA) is a natural polymer with high hydrophility. In the current study, novel Alg/PGA composite microparticles with double network structure were prepared by the emulsification/internal gelation method. It was found from the structure characterization that a double network structure was formed in the composite microparticles due to the ion chelation interaction between Ca2+ and the carboxylate groups of Alg and PGA and the electrostatic interaction between the secondary amine group of PGA and the carboxylate groups of Alg and PGA. The swelling behavior of the composite microparticles was significantly improved due to the high hydrophility of PGA. Influences of the preparing conditions on the swelling behavior of the composites were investigated. The porous microparticles could be formed while compositing of PGA. Thermal stability was studied by thermogravimetric analysis method. Moreover, in vitro cytocompatibility test of microparticles exhibited good biocompatibility with L929 cells. All results indicated that such Alg/PGA composite microparticles are a promising candidate in the field of wound dressing for hemostasis or rapid removal of exudates. View Full-Text
Keywords: alginate; poly(γ-glutamic acid); emulsification/internal gelation method; microparticle; swelling behavior alginate; poly(γ-glutamic acid); emulsification/internal gelation method; microparticle; swelling behavior
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tong, Z.; Chen, Y.; Liu, Y.; Tong, L.; Chu, J.; Xiao, K.; Zhou, Z.; Dong, W.; Chu, X. Preparation, Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles. Mar. Drugs 2017, 15, 91.

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