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Mar. Drugs 2017, 15(8), 247; doi:10.3390/md15080247

Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae

1
State Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, China
2
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China
*
Author to whom correspondence should be addressed.
Received: 19 June 2017 / Revised: 27 July 2017 / Accepted: 3 August 2017 / Published: 7 August 2017
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Abstract

Harmful algal blooms have become a great challenge to global aquatic ecosystems over the past decades. Given their low toxicity, high selectivity, and environment-friendly properties, the use of natural products and their analogues as algicides has proven to be particularly efficient. In the present study, algicidal activity of naturally occurring bacillamides A–C, alkaloid (1), and neobacillamide A, as well as their synthetic analogues were investigated intensively. Bioassay results showed that, relative to natural bacillamide alkaloids, aniline-derived analogue (10d) exhibited higher algicidal potential against three freshwater harmful algae Mycrocyctis aeruginosa, Scenedesmus obliquus, and Chlorella pyrenoidosa, suggesting that it could be used as a promising lead compound to develop novel algicide for controlling harmful algal blooms. View Full-Text
Keywords: algicide; bacillamide; thiazolamide; alleopathy algicide; bacillamide; thiazolamide; alleopathy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, B.; Tao, Y.; Liu, Q.; Liu, N.; Jin, Z.; Xu, X. Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae. Mar. Drugs 2017, 15, 247.

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