Table of Contents
Mar. Drugs, Volume 15, Issue 8 (August 2017)
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Cover Story With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a [...] Read more. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a wealth of information is being revealed about the secondary metabolism of marine proteobacteria. Numerous medically relevant natural products including novel leads for the treatment of multidrug-resistant pathogens and cancer have been identified from marine proteobacteria, whose secondary metabolites and biosynthetic mechanisms differ from those of other bacteria. Marine proteobacterial natural products feature frequent halogenation, sulfur-containing heterocycles, and non-ribosomal peptides/polyketides with unusual biosynthetic logic. Facilitated by technological advancements in the field this review focuses on genomics driven approaches to elucidating the biosynthetic mechanisms used by marine proteobacteria. View the paper