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Mar. Drugs, Volume 2, Issue 3 (September 2004), Pages 83-153

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Research

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Open AccessArticle Amphidinolide C2, New Macrolide from Marine Dinoflagellate Amphidinium Species
Mar. Drugs 2004, 2(3), 83-87; doi:10.3390/md203083
Received: 3 May 2004 / Accepted: 27 May 2004 / Published: 25 August 2004
Cited by 20 | PDF Full-text (56 KB) | HTML Full-text | XML Full-text
Abstract A new cytotoxic 25-membered macrolide, amphidinolide C2 (1), has been isolated from marine dinoflagellate Amphidinium sp. (Y-71 strain), and the structure 1 was elucidated on the basis of spectroscopic data and chemical means. Full article
Open AccessArticle New Alkaloids from the Mediterranean Sponge Hamigera hamigera
Mar. Drugs 2004, 2(3), 88-100; doi:10.3390/md203088
Received: 30 April 2004 / Accepted: 27 May 2004 / Published: 25 August 2004
Cited by 9 | PDF Full-text (179 KB) | HTML Full-text | XML Full-text
Abstract
The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1),
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The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), hamigeramine (2), hamigeramide (3) and hamiguanosinol (5). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry . Full article
Open AccessArticle Bioactive Chromodorolide Diterpenes from an Aplysillid Sponge
Mar. Drugs 2004, 2(3), 101-107; doi:10.3390/md203101
Received: 7 May 2004 / Accepted: 1 August 2004 / Published: 25 August 2004
Cited by 12 | PDF Full-text (46 KB) | HTML Full-text | XML Full-text
Abstract
The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and
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The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and also showed activity against the freeliving larval stages of the parasitic nematodes Haemonchus contortus and Trichostrongylus colubriformis. Full article
Open AccessArticle Healing and Preventive Effects of Calcium Alginate on Carbon Tetrachloride Induced Liver Injury in Rats
Mar. Drugs 2004, 2(3), 108-122; doi:10.3390/md203108
Received: 18 May 2004 / Accepted: 10 August 2004 / Published: 25 August 2004
Cited by 4 | PDF Full-text (124 KB) | HTML Full-text | XML Full-text
Abstract
The purpose of this study was to investigate the pharmacological effects of calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The study included two experiments. In the first experiment the animals were given daily CCL4 through gavage for 7
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The purpose of this study was to investigate the pharmacological effects of calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The study included two experiments. In the first experiment the animals were given daily CCL4 through gavage for 7 days and then 10, 50, or 250 mg/kg b.w. of calcium alginate for 21 days. The increased bilirubin level, enhanced alanine and aspartate aminotransferase activity in plasma and reduced liver glycogen content induced by CCL4 were partly normalized by alginate administration in a dose-dependent manner. In addition, alginate significantly improved CCL4-induced alterations of pro-oxidant and antioxidant biochemical parameters in liver and plasma compared to those of rats administered CCL4. In the second experiment the animals were given daily 10, 50 or 250 mg/kg b.w. of calcium alginate for 21 days before 7-day administration of CCL4. Pretreatment with alginate before CCL4 administration resulted in significantly inhibited increase of the blood enzymatic activities of alanine and aspartate aminotransferases and bilirubin level in a dose-dependent manner. Also, preliminary administration of alginate prevented elevation of lipid peroxidation products and reduction of liver glutathione content in rats given CCL4. These results suggest that calcium alginate exerts healing and preventive effects on CCL4-induced hepatotoxicity in rats. Full article
Open AccessArticle Antimicrobial Activity of Untenospongin B, a Metabolite from the Marine Sponge Hippospongia communis collected from the Atlantic Coast of Morocco
Mar. Drugs 2004, 2(3), 147-153; doi:10.3390/md203147
Received: 12 July 2004 / Accepted: 28 July 2004 / Published: 25 August 2004
Cited by 19 | PDF Full-text (70 KB) | HTML Full-text | XML Full-text
Abstract
(-)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity
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(-)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity was further characterized by determination of the minimum inhibitory concentration (MIC) against five fungal species using broth microdilution method. Full article

Review

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Open AccessReview Biomedical Compounds from Marine organisms
Mar. Drugs 2004, 2(3), 123-146; doi:10.3390/md203123
Received: 17 May 2004 / Accepted: 1 August 2004 / Published: 25 August 2004
Cited by 85 | PDF Full-text (121 KB) | HTML Full-text | XML Full-text
Abstract
The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of
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The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome (AIDS), arthritis, etc., while other compounds have been developed as analgesics or to treat inflammation, etc. The lifesaving drugs are mainly found abundantly in microorganisms, algae and invertebrates, while they are scarce in vertebrates. Modern technologies have opened vast areas of research for the extraction of biomedical compounds from oceans and seas. Full article

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