Carbon Nanomaterials: Efficacy and Safety for Nanomedicine
Abstract
:1. Introduction
Fullerenes | CNHs | CNTs | |
---|---|---|---|
Year of discovery | 1985 | 1998 | 1991 |
Discoverer | H.W. Kroto R.F. Curl R.E. Smalley | S. Iijima | S. Iijima |
Size | |||
Diameter Length | 1 nm - | 2–4 nm 40–70 nm | 0.4–70 nm 1 µm–2.5 mm |
Shape | sphere | horn | fiber |
Practical use | Cosmetics Lubricity agent Semiconductor | Fuel battery | Semiconductor Car parts Sports goods |
2. Utility of Carbon Nanomaterials for Nanomedicine
2.1. Fullerenes
2.2. CNHs/CNTs
2.3. Suitable Modification of Carbon Nanomaterials for DDS
2.4. Other Application of CNTs in Medicine
3. Safety of Carbon Nanomaterials
3.1. Hazard Assessment
3.2. Biological Behavior of CNTs
3.3. Development of Safe Nanomaterials
4. Conclusions
Acknowledgements
References
- Konstantatos, G.; Sargent, E.H. Nanostructured materials for photon detection. Nat. Nanotechnol. 2010, 5, 391–400. [Google Scholar] [CrossRef] [PubMed]
- Augustin, M.A.; Sanguansri, P. Nanostructured materials in the food industry. Adv. Food Nutr. Res. 2009, 58, 183–213. [Google Scholar] [PubMed]
- Bowman, D.M.; van Calster, G.; Friedrichs, S. Nanomaterials and regulation of cosmetics. Nat. Nanotechnol. 2010, 5, 92. [Google Scholar] [CrossRef] [PubMed]
- Petros, R.A.; DeSimone, J.M. Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discov. 2010, 9, 615–627. [Google Scholar] [CrossRef] [PubMed]
- Stern, S.T.; McNeil, S.E. Nanotechnology safety concerns revisited. Toxicol. Sci. 2008, 101, 4–21. [Google Scholar] [CrossRef] [PubMed]
- Lacerda, L.; Bianco, A.; Prato, M.; Kostarelos, K. Carbon nanotubes as nanomedicines: From toxicology to pharmacology. Adv. Drug Deliv. Rev. 2006, 58, 1460–1470. [Google Scholar] [CrossRef] [PubMed]
- Tiwari, A.K.; Gajbhiye, V.; Sharma, R.; Jain, N.K. Carrier mediated protein and peptide stabilization. Drug Deliv. 2010, 17, 605–616. [Google Scholar] [CrossRef] [PubMed]
- Martinez-Loran, E.; Alvarez-Zauco, E.; Basiuk, V.A.; Basiuk, E.V.; Bizarro, M. Fullerene thin films functionalized by 1,5-diaminonaphthalene: Preparation and properties. J. Nanosci. Nanotechnol. 2011, 11, 5569–5573. [Google Scholar] [CrossRef] [PubMed]
- Ci, L.; Ajayan, P.M. Modifying surface structure to tune surface properties of vertically aligned carbon nanotube films. J. Nanosci. Nanotechnol. 2010, 10, 3854–3859. [Google Scholar] [CrossRef] [PubMed]
- Velamakanni, A.; Magnuson, C.W.; Ganesh, K.J.; Zhu, Y.; An, J.; Ferreira, P.J.; Ruoff, R.S. Site-specific deposition of Au nanoparticles in CNT films by chemical bonding. ACS Nano 2010, 4, 540–546. [Google Scholar] [CrossRef] [PubMed]
- Ajima, K.; Yudasaka, M.; Murakami, T.; Maigne, A.; Shiba, K.; Iijima, S. Carbon nanohorns as anticancer drug carriers. Mol. Pharm. 2005, 2, 475–480. [Google Scholar] [CrossRef] [PubMed]
- Klumpp, C.; Kostarelos, K.; Prato, M.; Bianco, A. Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochim. Biophys. Acta 2006, 1758, 404–412. [Google Scholar] [CrossRef] [PubMed]
- Rodriguez-Zavala, J.G.; Guirado-Lopez, R.A. Stability of highly OH-covered C60 fullerenes: Role of coadsorbed O impurities and of the charge state of the cage in the formation of carbon-opened structures. J. Phys. Chem. A 2006, 110, 9459–9468. [Google Scholar] [CrossRef] [PubMed]
- Heister, E.; Lamprecht, C.; Neves, V.; Tilmaciu, C.; Datas, L.; Flahaut, E.; Soula, B.; Hinterdorfer, P.; Coley, H.M.; Silva, S.R.; McFadden, J. Higher dispersion efficacy of functionalized carbon nanotubes in chemical and biological environments. ACS Nano 2010, 4, 2615–2626. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Iohara, D.; Hirayama, F.; Higashi, K.; Yamamoto, K.; Uekama, K. Formation of stable hydrophilic C60 nanoparticles by 2-hydroxypropyl-beta-cyclodextrin. Mol. Pharm. 2011, 8, 1276–1284. [Google Scholar] [CrossRef] [PubMed]
- Weiss, D.R.; Raschke, T.M.; Levitt, M. How hydrophobic buckminsterfullerene affects surrounding water structure. J. Phys. Chem. B 2008, 112, 2981–2990. [Google Scholar] [CrossRef] [PubMed]
- Takagi, A.; Hirose, A.; Nishimura, T.; Fukumori, N.; Ogata, A.; Ohashi, N.; Kitajima, S.; Kanno, J. Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube. J. Toxicol. Sci. 2008, 33, 105–116. [Google Scholar] [CrossRef] [PubMed]
- Sakamoto, Y.; Nakae, D.; Fukumori, N.; Tayama, K.; Maekawa, A.; Imai, K.; Hirose, A.; Nishimura, T.; Ohashi, N.; Ogata, A. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J. Toxicol. Sci. 2009, 34, 65–76. [Google Scholar] [CrossRef] [PubMed]
- Poland, C.A.; Duffin, R.; Kinloch, I.; Maynard, A.; Wallace, W.A.; Seaton, A.; Stone, V.; Brown, S.; Macnee, W.; Donaldson, K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat. Nanotechnol. 2008, 3, 423–428. [Google Scholar] [CrossRef] [PubMed]
- Muller, J.; Delos, M.; Panin, N.; Rabolli, V.; Huaux, F.; Lison, D. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol. Sci. 2009, 110, 442–448. [Google Scholar] [CrossRef] [PubMed]
- Mateo-Alonso, A.; Guldi, D.M.; Paolucci, F.; Prato, M. Fullerenes: Multitask components in molecular machinery. Angew. Chem. Int. Ed. Engl. 2007, 46, 8120–8126. [Google Scholar] [CrossRef] [PubMed]
- Foley, S.; Crowley, C.; Smaihi, M.; Bonfils, C.; Erlanger, B.F.; Seta, P.; Larroque, C. Cellular localisation of a water-soluble fullerene derivative. Biochem. Biophys. Res. Commun. 2002, 294, 116–119. [Google Scholar] [CrossRef] [PubMed]
- Sitharaman, B.; Zakharian, T.Y.; Saraf, A.; Misra, P.; Ashcroft, J.; Pan, S.; Pham, Q.P.; Mikos, A.G.; Wilson, L.J.; Engler, D.A. Water-soluble fullerene (C60) derivatives as nonviral gene-delivery vectors. Mol. Pharm. 2008, 5, 567–578. [Google Scholar] [CrossRef] [PubMed]
- Zakharian, T.Y.; Seryshev, A.; Sitharaman, B.; Gilbert, B.E.; Knight, V.; Wilson, L.J. A fullerene-paclitaxel chemotherapeutic: Synthesis, characterization, and study of biological activity in tissue culture. J. Am. Chem. Soc. 2005, 127, 12508–12509. [Google Scholar] [CrossRef] [PubMed]
- Maeda-Mamiya, R.; Noiri, E.; Isobe, H.; Nakanishi, W.; Okamoto, K.; Doi, K.; Sugaya, T.; Izumi, T.; Homma, T.; Nakamura, E. In vivo gene delivery by cationic tetraamino fullerene. Proc. Natl. Acad. Sci. USA 2010, 107, 5339–5344. [Google Scholar] [CrossRef] [PubMed]
- Chen, T.; Li, Y.Y.; Zhang, J.L.; Xu, B.; Lin, Y.; Wang, C.X.; Guan, W.C.; Wang, Y.J.; Xu, S.Q. Protective effect of C(60)-methionine derivate on lead-exposed human SH-SY5Y neuroblastoma cells. J. Appl. Toxicol. 2011, 31, 255–261. [Google Scholar] [CrossRef] [PubMed]
- Huang, S.S.; Tsai, S.K.; Chih, C.L.; Chiang, L.Y.; Hsieh, H.M.; Teng, C.M.; Tsai, M.C. Neuroprotective effect of hexasulfobutylated C60 on rats subjected to focal cerebral ischemia. Free Radic. Biol. Med. 2001, 30, 643–649. [Google Scholar] [CrossRef] [PubMed]
- Huang, S.T.; Ho, C.S.; Lin, C.M.; Fang, H.W.; Peng, Y.X. Development and biological evaluation of C(60) fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent. Bioorg. Med. Chem. 2008, 16, 8619–8626. [Google Scholar] [CrossRef] [PubMed]
- Zhu, S.; Xu, G. Single-walled carbon nanohorns and their applications. Nanoscale 2010, 2, 2538–2549. [Google Scholar] [CrossRef] [PubMed]
- Awasthi, K.; Srivastava, A.; Srivastava, O.N. Synthesis of carbon nanotubes. J. Nanosci. Nanotechnol. 2005, 5, 1616–1636. [Google Scholar] [CrossRef] [PubMed]
- Liu, Z.; Winters, M.; Holodniy, M.; Dai, H. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew. Chem. Int. Ed. Engl. 2007, 46, 2023–207. [Google Scholar] [CrossRef] [PubMed]
- Zhang, X.; Meng, L.; Lu, Q.; Fei, Z.; Dyson, P.J. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 2009, 30, 6041–6047. [Google Scholar] [CrossRef] [PubMed]
- Liu, Z.; Sun, X.; Nakayama-Ratchford, N.; Dai, H. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 2007, 1, 50–56. [Google Scholar] [CrossRef] [PubMed]
- Pardasani, D.; Kanaujia, P.K.; Purohit, A.K.; Shrivastava, A.R.; Dubey, D.K. Magnetic multi-walled carbon nanotubes assisted dispersive solid phase extraction of nerve agents and their markers from muddy water. Talanta 2011, 86, 248–255. [Google Scholar] [CrossRef] [PubMed]
- Ou, Z.; Wu, B.; Xing, D.; Zhou, F.; Wang, H.; Tang, Y. Functional single-walled carbon nanotubes based on an integrin alpha v beta 3 monoclonal antibody for highly efficient cancer cell targeting. Nanotechnology 2009, 20, 105102. [Google Scholar] [CrossRef] [PubMed]
- Cheng, W.; Ding, L.; Lei, J.; Ding, S.; Ju, H. Effective cell capture with tetrapeptide-functionalized carbon nanotubes and dual signal amplification for cytosensing and evaluation of cell surface carbohydrate. Anal. Chem. 2008, 80, 3867–3872. [Google Scholar] [CrossRef] [PubMed]
- Lu, Y.J.; Wei, K.C.; Ma, C.C.; Yang, S.Y.; Chen, J.P. Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids Surf. B. 2012, 89, 1–9. [Google Scholar] [CrossRef]
- Wang, C.H.; Chiou, S.H.; Chou, C.P.; Chen, Y.C.; Huang, Y.J.; Peng, C.A. Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody. Nanomedicine 2011, 7, 69–79. [Google Scholar] [CrossRef] [PubMed]
- Ruggiero, A.; Villa, C.H.; Bander, E.; Rey, D.A.; Bergkvist, M.; Batt, C.A.; Manova-Todorova, K.; Deen, W.M.; Scheinberg, D.A.; McDevitt, M.R. Paradoxical glomerular filtration of carbon nanotubes. Proc. Natl. Acad. Sci. USA 2010, 107, 12369–12374. [Google Scholar] [CrossRef] [PubMed]
- Geng, R.; Li, Z.; Li, S.; Gao, J. Proteomics in pancreatic cancer research. Int. J. Proteomics 2011, 2011, 365350. [Google Scholar] [CrossRef] [PubMed]
- Taylor, B.S.; Ladanyi, M. Clinical cancer genomics: How soon is now? J. Pathol. 2011, 223, 318–326. [Google Scholar] [CrossRef] [PubMed]
- Bathen, T.F.; Sitter, B.; Sjobakk, T.E.; Tessem, M.B.; Gribbestad, I.S. Magnetic resonance metabolomics of intact tissue: A biotechnological tool in cancer diagnostics and treatment evaluation. Cancer Res. 2010, 70, 6692–6696. [Google Scholar] [CrossRef] [PubMed]
- Imai, S.; Nagano, K.; Yoshida, Y.; Okamura, T.; Yamashita, T.; Abe, Y.; Yoshikawa, T.; Yoshioka, Y.; Kamada, H.; Mukai, Y.; et al. Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins. Biomaterials 2010, 32, 162–169. [Google Scholar] [CrossRef] [PubMed]
- Fang, J.; Sawa, T.; Maeda, H. Factors and mechanism of “EPR” effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv. Exp. Med. Biol. 2003, 519, 29–49. [Google Scholar] [PubMed]
- Yang, K.; Wan, J.; Zhang, S.; Zhang, Y.; Lee, S.T.; Liu, Z. In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. ACS Nano 2010, 5, 516–522. [Google Scholar] [CrossRef] [PubMed]
- Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin, G.; Klumpp, C.; Prato, M.; Bianco, A.; Kostarelos, K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl. Acad. Sci. USA 2006, 103, 3357–3362. [Google Scholar] [CrossRef] [PubMed]
- De la Zerda, A.; Zavaleta, C.; Keren, S.; Vaithilingam, S.; Bodapati, S.; Liu, Z.; Levi, J.; Smith, B.R.; Ma, T.J.; Oralkan, O.; et al. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat. Nanotechnol. 2008, 3, 557–562. [Google Scholar]
- Tosun, Z.; McFetridge, P.S. A composite SWNT-collagen matrix: Characterization and preliminary assessment as a conductive peripheral nerve regeneration matrix. J. Neural Eng. 2010, 7, 066002. [Google Scholar] [CrossRef] [PubMed]
- Uo, M.; Akasaka, T.; Watari, F.; Sato, Y.; Tohji, K. Toxicity evaluations of various carbon nanomaterials. Dent. Mater. J. 2011, 30, 245–263. [Google Scholar] [CrossRef] [PubMed]
- Vankoningsloo, S.; Piret, J.P.; Saout, C.; Noel, F.; Mejia, J.; Zouboulis, C.C.; Delhalle, J.; Lucas, S.; Toussaint, O. Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: Effects of sonication, dispersive agents and corneous layer of reconstructed epidermis. Nanotoxicology 2010, 4, 84–97. [Google Scholar] [CrossRef] [PubMed]
- Sargent, L.M.; Reynolds, S.H.; Castranova, V. Potential pulmonary effects of engineered carbon nanotubes: In vitro genotoxic effects. Nanotoxicology 2010, 4, 396–408. [Google Scholar] [CrossRef] [PubMed]
- Naya, M.; Kobayashi, N.; Mizuno, K.; Matsumoto, K.; Ema, M.; Nakanishi, J. Evaluation of the genotoxic potential of single-wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays. Regul. Toxicol. Pharmacol. 2011, 61, 192–198. [Google Scholar] [CrossRef] [PubMed]
- Magrez, A.; Kasas, S.; Salicio, V.; Pasquier, N.; Seo, J.W.; Celio, M.; Catsicas, S.; Schwaller, B.; Forro, L. Cellular toxicity of carbon-based nanomaterials. Nano Lett. 2006, 6, 1121–1125. [Google Scholar] [CrossRef] [PubMed]
- Jacobsen, N.R.; Pojana, G.; White, P.; Moller, P.; Cohn, C.A.; Korsholm, K.S.; Vogel, U.; Marcomini, A.; Loft, S.; Wallin, H. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells. Environ. Mol. Mutagen. 2008, 49, 476–487. [Google Scholar] [CrossRef] [PubMed]
- Di Sotto, A.; Chiaretti, M.; Carru, G.A.; Bellucci, S.; Mazzanti, G. Multi-walled carbon nanotubes: Lack of mutagenic activity in the bacterial reverse mutation assay. Toxicol. Lett. 2009, 184, 192–197. [Google Scholar]
- Nagai, H.; Okazaki, Y.; Chew, S.H.; Misawa, N.; Yamashita, Y.; Akatsuka, S.; Ishihara, T.; Yamashita, K.; Yoshikawa, Y.; Yasui, H.; et al. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc. Natl. Acad. Sci. USA 2011, 108, E1330–E1338. [Google Scholar] [CrossRef] [PubMed]
- Shvedova, A.A.; Kisin, E.; Murray, A.R.; Johnson, V.J.; Gorelik, O.; Arepalli, S.; Hubbs, A.F.; Mercer, R.R.; Keohavong, P.; Sussman, N.; et al. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: Inflammation, fibrosis, oxidative stress, and mutagenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295, L552–L565. [Google Scholar] [CrossRef] [PubMed]
- Shvedova, A.A.; Kisin, E.R.; Mercer, R.; Murray, A.R.; Johnson, V.J.; Potapovich, A.I.; Tyurina, Y.Y.; Gorelik, O.; Arepalli, S.; Schwegler-Berry, D.; et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 289, L698–L708. [Google Scholar] [CrossRef] [PubMed]
- Johnston, H.J.; Hutchison, G.R.; Christensen, F.M.; Peters, S.; Hankin, S.; Aschberger, K.; Stone, V. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology 2010, 4, 207–246. [Google Scholar] [CrossRef] [PubMed]
- Donaldson, K.; Murphy, F.; Schinwald, A.; Duffin, R.; Poland, C.A. Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design. Nanomedicine 2011, 6, 143–156. [Google Scholar] [CrossRef] [PubMed]
- Donaldson, K.; Murphy, F.A.; Duffin, R.; Poland, C.A. Asbestos, carbon nanotubes and the pleural mesothelium: A review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part. Fibre Toxicol. 2010, 7, 5. [Google Scholar] [CrossRef] [PubMed]
- Migliore, L.; Saracino, D.; Bonelli, A.; Colognato, R.; D’Errico, M.R.; Magrini, A.; Bergamaschi, A.; Bergamaschi, E. Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells. Environ. Mol. Mutagen. 2010, 51, 294–303. [Google Scholar] [PubMed]
- Vittorio, O.; Raffa, V.; Cuschieri, A. Influence of purity and surface oxidation on cytotoxicity of multiwalled carbon nanotubes with human neuroblastoma cells. Nanomedicine 2009, 5, 424–431. [Google Scholar] [CrossRef] [PubMed]
- Dostert, C.; Petrilli, V.; Van Bruggen, R.; Steele, C.; Mossman, B.T.; Tschopp, J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320, 674–677. [Google Scholar] [CrossRef] [PubMed]
- Palomaki, J.; Valimaki, E.; Sund, J.; Vippola, M.; Clausen, P.A.; Jensen, K.A.; Savolainen, K.; Matikainen, S.; Alenius, H. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 2011, 5, 6861–6870. [Google Scholar] [CrossRef] [PubMed]
- Yang, S.T.; Wang, X.; Jia, G.; Gu, Y.; Wang, T.; Nie, H.; Ge, C.; Wang, H.; Liu, Y. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol. Lett. 2008, 181, 182–189. [Google Scholar] [CrossRef] [PubMed]
- Wick, P.; Manser, P.; Limbach, L.K.; Dettlaff-Weglikowska, U.; Krumeich, F.; Roth, S.; Stark, W.J.; Bruinink, A. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol. Lett. 2007, 168, 121–131. [Google Scholar] [CrossRef] [PubMed]
- Murray, A.R.; Kisin, E.; Leonard, S.S.; Young, S.H.; Kommineni, C.; Kagan, V.E.; Castranova, V.; Shvedova, A.A. Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. Toxicology 2009, 257, 161–171. [Google Scholar] [CrossRef] [PubMed]
- Aschberger, K.; Johnston, H.J.; Stone, V.; Aitken, R.J.; Hankin, S.M.; Peters, S.A.; Tran, C.L.; Christensen, F.M. Review of carbon nanotubes toxicity and exposure—Appraisal of human health risk assessment based on open literature. Crit. Rev. Toxicol. 2010, 40, 759–790. [Google Scholar] [CrossRef] [PubMed]
- Ai, J.; Biazar, E.; Jafarpour, M.; Montazeri, M.; Majdi, A.; Aminifard, S.; Zafari, M.; Akbari, H.R.; Rad, H.G. Nanotoxicology and nanoparticle safety in biomedical designs. Int. J. Nanomed. 2011, 6, 1117–1127. [Google Scholar]
- Stefani, D.; Paula, A.J.; Vaz, B.G.; Silva, R.A.; Andrade, N.F.; Justo, G.Z.; Ferreira, C.V.; Filho, A.G.; Eberlin, M.N.; Alves, O.L. Structural and proactive safety aspects of oxidation debris from multiwalled carbon nanotubes. J. Hazard Mater. 2011, 189, 391–396. [Google Scholar] [CrossRef] [PubMed]
- Rourke, J.P.; Pandey, P.A.; Moore, J.J.; Bates, M.; Kinloch, I.A.; Young, R.J.; Wilson, N.R. The real graphene oxide revealed: Stripping the oxidative debris from the graphene-like sheets. Angew. Chem. Int. Ed. Engl. 2011, 50, 3173–3177. [Google Scholar] [CrossRef] [PubMed]
- Fogden, S.; Verdejo, R.; Cottam, B.; Shaffer, M. Purification of single walled carbon nanotubes: The problem with oxidation debris. Chem. Phys. Lett. 2008, 460, 162–167. [Google Scholar] [CrossRef]
- Ryman-Rasmussen, J.P.; Cesta, M.F.; Brody, A.R.; Shipley-Phillips, J.K.; Everitt, J.I.; Tewksbury, E.W.; Moss, O.R.; Wong, B.A.; Dodd, D.E.; Andersen, M.E.; et al. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat. Nanotechnol. 2009, 4, 747–751. [Google Scholar] [CrossRef] [PubMed]
- Kagan, V.E.; Konduru, N.V.; Feng, W.; Allen, B.L.; Conroy, J.; Volkov, Y.; Vlasova, I.I.; Belikova, N.A.; Yanamala, N.; Kapralov, A.; et al. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat. Nanotechnol. 2010, 5, 354–359. [Google Scholar] [CrossRef] [PubMed]
- Liu, X.; Hurt, R.H.; Kane, A.B. Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon 2010, 48, 1961–1969. [Google Scholar] [CrossRef] [PubMed]
- Yamashita, K.; Yoshioka, Y.; Higashisaka, K.; Morishita, Y.; Yoshida, T.; Fujimura, M.; Kayamuro, H.; Nabeshi, H.; Yamashita, T.; Nagano, K.; et al. Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape. Inflammation 2010, 33, 276–280. [Google Scholar] [CrossRef] [PubMed]
- Coccini, T.; Roda, E.; Sarigiannis, D.A.; Mustarelli, P.; Quartarone, E.; Profumo, A.; Manzo, L. Effects of water-soluble functionalized multi-walled carbon nanotubes examined by different cytotoxicity methods in human astrocyte D384 and lung A549 cells. Toxicology 2010, 269, 41–53. [Google Scholar] [CrossRef] [PubMed]
- Nabeshi, H.; Yoshikawa, T.; Matsuyama, K.; Nakazato, Y.; Matsuo, K.; Arimori, A.; Isobe, M.; Tochigi, S.; Kondoh, S.; Hirai, T.; et al. Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials 2011, 32, 2713–2724. [Google Scholar] [CrossRef] [PubMed]
- Nabeshi, H.; Yoshikawa, T.; Matsuyama, K.; Nakazato, Y.; Tochigi, S.; Kondoh, S.; Hirai, T.; Akase, T.; Nagano, K.; Abe, Y.; et al. Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes. Part. Fibre Toxicol. 2011, 8, 1. [Google Scholar] [CrossRef] [PubMed]
- Nabeshi, H.; Yoshikawa, T.; Arimori, A.; Yoshida, T.; Tochigi, S.; Hirai, T.; Akase, T.; Nagano, K.; Abe, Y.; Kamada, H.; et al. Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages. Nanoscale Res. Lett. 2011, 6, 93. [Google Scholar] [CrossRef] [PubMed]
- Lundqvist, M.; Stigler, J.; Elia, G.; Lynch, I.; Cedervall, T.; Dawson, K.A. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc. Natl. Acad. Sci. USA 2008, 105, 14265–14270. [Google Scholar] [CrossRef] [PubMed]
- Sund, J.; Alenius, H.; Vippola, M.; Savolainen, K.; Puustinen, A. Proteomic characterization of engineered nanomaterial-protein interactions in relation to surface reactivity. ACS Nano 2011, 5, 4300–4309. [Google Scholar] [CrossRef] [PubMed]
- Gasser, M.; Rothen-Rutishauser, B.; Krug, H.F.; Gehr, P.; Nelle, M.; Yan, B.; Wick, P. The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry. J. Nanobiotechnol. 2010, 8, 31. [Google Scholar] [CrossRef]
- Moghimi, S.M.; Hunter, A.C. Complement monitoring of carbon nanotubes. Nat. Nanotechnol. 2010, 5, 382. [Google Scholar] [CrossRef] [PubMed]
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Yamashita, T.; Yamashita, K.; Nabeshi, H.; Yoshikawa, T.; Yoshioka, Y.; Tsunoda, S.-i.; Tsutsumi, Y. Carbon Nanomaterials: Efficacy and Safety for Nanomedicine. Materials 2012, 5, 350-363. https://doi.org/10.3390/ma5020350
Yamashita T, Yamashita K, Nabeshi H, Yoshikawa T, Yoshioka Y, Tsunoda S-i, Tsutsumi Y. Carbon Nanomaterials: Efficacy and Safety for Nanomedicine. Materials. 2012; 5(2):350-363. https://doi.org/10.3390/ma5020350
Chicago/Turabian StyleYamashita, Takuya, Kohei Yamashita, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, and Yasuo Tsutsumi. 2012. "Carbon Nanomaterials: Efficacy and Safety for Nanomedicine" Materials 5, no. 2: 350-363. https://doi.org/10.3390/ma5020350