Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy
AbstractData from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 12664 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Carracedo Rodriguez, A.; Chung, M.; Ciupe, S.M. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy. Viruses 2017, 9, 117.
Carracedo Rodriguez A, Chung M, Ciupe SM. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy. Viruses. 2017; 9(5):117.Chicago/Turabian Style
Carracedo Rodriguez, Andrea; Chung, Matthias; Ciupe, Stanca M. 2017. "Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy." Viruses 9, no. 5: 117.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.