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Viruses 2017, 9(5), 117; doi:10.3390/v9050117

Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy

Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA
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Author to whom correspondence should be addressed.
Academic Editors: John Murray and Ruy Ribeiro
Received: 17 February 2017 / Revised: 21 April 2017 / Accepted: 2 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue Mathematical Modeling of Viral Infections)
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Abstract

Data from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles. View Full-Text
Keywords: virus kinetics; hepatitis B virus (HBV); drug therapy; Monte Carlo virus kinetics; hepatitis B virus (HBV); drug therapy; Monte Carlo
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Carracedo Rodriguez, A.; Chung, M.; Ciupe, S.M. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy. Viruses 2017, 9, 117.

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