Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Single Nuclotide Polymorphism (SNP) Selection and Hardy–Weinberg Equilibrium (HWE)
2.3. Statistical Analyses
3. Results
3.1. Participants Characteristics
3.2. TMEM18 SNPs Associated with Obesity Risk
3.3. TMEM18 rs939583 and rs1879523 Interaction with Actionable Lifestyle Factors
3.3.1. PA
3.3.2. Wine Consumption
3.3.3. SSBs
3.3.4. Flavored Water Consumption
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All Population n = 3089 | Obese Subjects (BMI ≥ 30) n = 1743 | Non-Obese Subjects (BMI < 30) n = 1346 | p Value | |
---|---|---|---|---|
Gender (women, %) | 2136 (69.1%) | 1155 (66.3%) | 981 (72.88%) | <0.001 |
Age (mean ± SD, min, max) | 55.21 ± 14.31 (18, 89) | 55.49 ± 14.52 (18, 88) | 54.85 ± 14.04 (18, 89) | 0.11 |
Weight (mean ± SD, min, max) | 87.86 ± 19.18 (40, 185) | 98.69 ± 17.08 (64, 185) | 73.82 ± 10.87 (40, 110) | <0.0001 |
Height (mean ± SD, min, max) | 166.78 ± 8.89 (138, 198) | 167.02 ± 9.18 (143, 198) | 166.46 ± 8.5 (138, 195) | 0.06 |
BMI (mean ± SD, min, max) | (31.49 ± 6.24) 15.24, 62 | 35.32 ± 5.51 (15.24, 29.98) | 26.55 ± 2.55 (30, 62) | <0.0001 |
Physically active (n, %) | 1621 (52.5%) | 779 (44.7%) | 842 (62.6%) | <0.001 |
Smoking (n, %) | 310 (10%) | 162 (9.3%) | 148 (11.0%) | 0.13 |
SSB Consumers (n, %) | 364 (11.8%) | 241 (13.8%) | 123 (9.1%) | <0.001 |
Wine Consumers (n, %) | 732 (23.7%) | 364 (20.9%) | 368 (27.3%) | <0.001 |
Flavored water Consumers (n, %) | 209 (6.8%) | 134 (7.7) | 75 (5.6%) | 0.02 |
Genotype Frequency (%) | p Value OR ± 95%(CI) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
SNP | Allele | Overall Population | Obese (n = 1743) | Non-Obese (n = 1346) | Dominant Model | Recessive Model | Additive Model | Codominant Model | Allelic Model | |
rs939583 (n = 3089) | C > T | CC TC TT | 168 (5.4%) 1061 (34.3%) 1860 (60.2%) | 85 (4.9%) 554 (31.8%) 1104 (63.3%) | 83 (6.2%) 507 (37.7%) 756 (56.1%) | 0.12 1.28 (0.94–1.75) | <0.001 1.35 (1.17–1.57) | <0.001 1.27 (1.13–1.43) | 0.03 1.43 (1.04–1.96) | 0.00004 1.27 (1.27–1.43) |
rs18719523 (n = 3089) | A > T | AA AT TT | 1458 (47.2%) 1341 (43.4%) 290 (9.4%) | 791 (45.4%) 757 (43.4%) 195 (11.2%) | 667 (49.6%) 584 (43.4%) 95 (7.1%) | <0.02 1.18 (1.03–1.36) | <0.001 1.66 (1.29–2.15) | <0.001 1.22 (1.09–1.36) | <0.001 1.73 (1.33–2.26) | 0.0002 1.22 (1.09–1.36) |
SNP | Actionable Factors | β | OR ± CI | p Value |
---|---|---|---|---|
rs939583 | PA | −0.3 | 0.74 (0.68–0.8) | <0.001 |
SSBs | 0.270 | 1.31 (1.14–1.51) | <0.001 | |
Flavored water | 0.298 | 1.35 (1.13–1.62) | 0.001 | |
Wine | −0.198 | 0.82 (0.74–0.9) | <0.001 | |
rs1879523 | PA | −0.223 | 0.8 (0.7–0.9) | <0.001 |
SSBs | 0.446 | 1.66 (1.26–2.26) | <0.001 | |
Flavored water | 0.499 | 1.65 (1.17–2.33) | 0.005 | |
Wine | −0.219 | 0.8 (0.67–0.96) | 0.02 |
PA Duration (Minutes) | SNP | BMI (Mean ±SD) | p Value * Ref: Inactive | p Value * Ref: Previous Duration Group |
---|---|---|---|---|
Not active (n = 1542) | rs939583 | 32.98 0.2 | ||
30 min (n = 407) | 32.27 0.67 | <0.005 | 0.005 | |
60 min (n = 552) | 31.16 0.3 | <0.001 | 0.232 | |
90 min (n = 238) | 29.91 0.4 | <0.001 | 0.01 | |
120 min (n = 171) | 29.49 0.43 | <0.001 | 0.57 | |
Above 120 min (n = 62) | 28.01 0.64 | <0.001 | 0.9 |
Wine Consuming | SSBs Consuming | |||||||
---|---|---|---|---|---|---|---|---|
β | OR ± CI | p Value | β | OR ± CI | p Value | |||
rs939583 | CC (n = 168) | −0.087 | 0.92 (0.46–1.82) | 0.8 | CC (n = 169) | 0.778 | 2.18 (0.85–5.56) | 0.1 |
CT (n = 1061) | −0.508 | 0.6 (0.45–0.8) | <0.001 | CT (n = 1062) | 0.576 | 1.78 (1.2–2.63) | 0.004 | |
TT (n = 1860) | −0.427 | 0.65 (0.52–0.81) | <0.001 | TT (n = 1860) | 0.391 | 1.47 (1.08–2.02) | 0.01 |
β | OR ± CI | p Value | ||
---|---|---|---|---|
rs939583 | CC (n = 111) | −0.497 | 0.6 (0.14–2.67) | 0.51 |
TC (n = 688) | 0.263 | 1.3 (0.72–2.36) | 0.39 | |
TT (n = 1202) | 0.761 | 2.14 (1.3–3.54) | 0.003 | |
TT vs. CC + TC (n = 2138) | 0.99 | 2.69 (1.28–3.65) | 0.009 | |
TT vs. CC (n = 1313) | 1.8 | 6.14 (1.4–27.1) | 0.017 |
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Chermon, D.; Birk, R. Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers. Nutrients 2023, 15, 266. https://doi.org/10.3390/nu15020266
Chermon D, Birk R. Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers. Nutrients. 2023; 15(2):266. https://doi.org/10.3390/nu15020266
Chicago/Turabian StyleChermon, Danyel, and Ruth Birk. 2023. "Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers" Nutrients 15, no. 2: 266. https://doi.org/10.3390/nu15020266