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Nutrients 2012, 4(11), 1610-1621; doi:10.3390/nu4111610
Review

Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review

 and
*
Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA
* Author to whom correspondence should be addressed.
Received: 17 August 2012 / Revised: 26 October 2012 / Accepted: 30 October 2012 / Published: 6 November 2012
(This article belongs to the Special Issue Dietary Minerals)
View Full-Text   |   Download PDF [606 KB, uploaded 6 November 2012]   |  

Abstract

Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.
Keywords: vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause vitamin D; phytoestrogen; soy isoflavones; bone; postmenopause
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Park, C.Y.; Weaver, C.M. Vitamin D Interactions with Soy Isoflavones on Bone after Menopause: A Review. Nutrients 2012, 4, 1610-1621.

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