The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada
AbstractWe determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (≤29 nmol/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p < 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI −19.8, −5.8), Coef. 7.85 units (95% CI −14.9, −0.7), Coef. 9.87 units (95% CI −17.6, −2.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category. However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn’s disease, particularly with the objective measures of inflammation. View Full-Text
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Alrefai, D.; Jones, J.; El-Matary, W.; Whiting, S.J.; Aljebreen, A.; Mirhosseini, N.; Vatanparast, H. The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada. Nutrients 2017, 9, 1112.
Alrefai D, Jones J, El-Matary W, Whiting SJ, Aljebreen A, Mirhosseini N, Vatanparast H. The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada. Nutrients. 2017; 9(10):1112.Chicago/Turabian Style
Alrefai, Dania; Jones, Jennifer; El-Matary, Wael; Whiting, Susan J.; Aljebreen, Abdulrahman; Mirhosseini, Naghmeh; Vatanparast, Hassan. 2017. "The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada." Nutrients 9, no. 10: 1112.
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