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Nutrients 2017, 9(3), 308; doi:10.3390/nu9030308

Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

Hospital Clínico Universitario “Lozano Blesa”, Avenue San Juan Bosco, 15, Zaragoza 50009, Aragón, Spain
Aragón Health Research Institute (IIS Aragón), Zaragoza 50009, Aragón, Spain
University of Zaragoza, Zaragoza 50009, Aragón, Spain
Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid 28029, Spain
Hospital Universitario de Salamanca, Salamanca 37007, Castilla y León, Spain
Hospital Universitario Miguel Servet, Zaragoza 50009, Aragón, Spain
Hospital Ernest Lluch Martin, Calatayud, Zaragoza 50299, Aragón, Spain
Hospital Virgen de la Concha, Zamora 49022, Castilla y León, Spain
Fernando Gomollón and Carla J. Gargallo is dual first authorship due to equal contribution.
Author to whom correspondence should be addressed.
Received: 18 January 2017 / Revised: 23 February 2017 / Accepted: 13 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue Nutrition and Diet in IBD)
View Full-Text   |   Download PDF [610 KB, uploaded 20 March 2017]   |  


Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a multicenter retrospective cohort study that included 94 patients with Crohn’s disease and cobalamin deficiency. Seventy-six patients had B12 deficiency and 94.7% of them normalized their cobalamin levels with oral treatment. The most used dose was 1 mg/day, but there were no significant differences in treatment effectiveness depending on the dose used (≥1 mg/24 h vs. <1 mg/24 h). Eighty-two patients had previous documented B12 deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitamin B12 deficiency caused by CD with or without ileum resection. View Full-Text
Keywords: vitamin B12 deficiency; cobalamin deficiency; Crohn’s disease; ileal resection; oral treatment; acute treatment; maintenance treatment vitamin B12 deficiency; cobalamin deficiency; Crohn’s disease; ileal resection; oral treatment; acute treatment; maintenance treatment

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Gomollón, F.; Gargallo, C.J.; Muñoz, J.F.; Vicente, R.; Lue, A.; Mir, A.; García-Alvarado, M.; Gracia, M.; García-López, S. Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease. Nutrients 2017, 9, 308.

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