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Nutrients 2017, 9(9), 1002; doi:10.3390/nu9091002

A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren

1
Food and Nutrition Research Institute, Department of Science and Technology, 1632 Taguig, Philippines
2
Formerly with the Global Alliance for Improved Nutrition (GAIN), Rue de Varembre 7, 1202 Geneve, Switzerland
3
Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30301, USA
4
Baylor College of Medicine, Departments of Internal Medicine, Pediatrics, Global Initiatives, and Center for Space Medicine, Houston, TX 77030, USA
5
University of Toronto, Center for Global Child Health, The Hospital for Sick Children, Toronto, ON M6S 1S6, Canada
*
Author to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 22 August 2017 / Accepted: 24 August 2017 / Published: 12 September 2017
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Abstract

This study evaluated the effects of a multi-micronutrient fortified juice drink given in different frequencies of consumption on hemoglobin (Hb) concentration of schoolchildren. Hb was measured in 2423 schoolchildren aged 6- to 9-years-old at baseline. All anemic children (n = 246) were randomly allocated into groups: Daily dose (HD: high dose), 5X/week (MD: Moderate Dose), 3X/week (LD: Low Dose) and unfortified (Control). Pre- and post-study measurements of micronutrients were collected from 228 children. At the endpoint, significant Hb increases were observed in all groups, but there was no significant difference between groups. There was a significant reduction in anemia prevalence in all groups from 100% to 36% (Control), 30% (LD), 23% (MD) and 26% (HD). No dose-response effect was observed in Hb in this population. Most likely, this resulted from better than expected micronutrient status and lower than expected severity of anemia and micronutrient deficiencies in this cohort. It is unlikely that the addition of a fortified beverage to school feeding programs in this population would have a positive impact. Whether such an intervention would be cost-effective as a preventative approach needs to be assessed. This study demonstrates the importance of targeting such interventions to appropriate populations. View Full-Text
Keywords: hemoglobin 1; dose response 2; multi-nutrient fortified juice drink 3 hemoglobin 1; dose response 2; multi-nutrient fortified juice drink 3
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Angeles-Agdeppa, I.; Magsadia, C.R.; Aaron, G.J.; Lloyd, B.B.; Hilmers, D.C.; Bhutta, Z.A. A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren. Nutrients 2017, 9, 1002.

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