Next Article in Journal
Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions)
Previous Article in Journal
The Aspergillus flavus Homeobox Gene, hbx1, is Required for Development and Aflatoxin Production
Previous Article in Special Issue
The Middle Fragment of Helicobacter pylori CagA Induces Actin Rearrangement and Triggers Its Own Uptake into Gastric Epithelial Cells
Article Menu

Export Article

Open AccessReview
Toxins 2017, 9(10), 316; doi:10.3390/toxins9100316

Helicobacter pylori Vacuolating Toxin and Gastric Cancer

1
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
2
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
3
Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jean E. Crabtree and Silja Wessler
Received: 13 September 2017 / Revised: 3 October 2017 / Accepted: 5 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue H. pylori Virulence Factors in the Induction of Gastric Cancer)
View Full-Text   |   Download PDF [937 KB, uploaded 12 October 2017]   |  

Abstract

Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer. View Full-Text
Keywords: Helicobacter pylori; gastric cancer; pore-forming toxins Helicobacter pylori; gastric cancer; pore-forming toxins
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

McClain, M.S.; Beckett, A.C.; Cover, T.L. Helicobacter pylori Vacuolating Toxin and Gastric Cancer. Toxins 2017, 9, 316.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top