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Toxins 2017, 9(5), 169; doi:10.3390/toxins9050169

Development of a LC-MS/MS Method for the Multi-Mycotoxin Determination in Composite Cereal-Based Samples

GMO and Mycotoxin Unit, Food Safety, Nutrition and Veterinary Public Health Department, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy
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Academic Editor: Aldo Laganà
Received: 7 April 2017 / Revised: 8 May 2017 / Accepted: 10 May 2017 / Published: 18 May 2017
(This article belongs to the Special Issue LC-MS/MS Method for Mycotoxin Analysis)
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Abstract

The analytical scenario for determining contaminants in the food and feed sector is constantly prompted by the progress and improvement of knowledge and expertise of researchers and by the technical innovation of the instrumentation available. Mycotoxins are agricultural contaminants of fungal origin occurring at all latitudes worldwide and being characterized by acute and chronic effects on human health and animal wellness, depending on the species sensitivity. The major mycotoxins of food concern are aflatoxin B1 and ochratoxin A, the first for its toxicity, and the second for its recurrent occurrence. However, the European legislation sets maximum limits for mycotoxins, such as aflatoxin B1, ochratoxin A, deoxynivalenol, fumonisins, and zearalenone, and indicative limits for T-2 and HT-2 toxins. Due to the actual probability that co-occurring mycotoxins are present in a food or feed product, nowadays, the availability of reliable, sensitive, and versatile multi-mycotoxin methods is assuming a relevant importance. Due to the wide range of matrices susceptible to mycotoxin contamination and the possible co-occurrence, a multi-mycotoxin and multi-matrix method was validated in liquid chromatography-tandem mass spectrometry (LC-MS/MS) with the purpose to overcome specific matrix effects and analyze complex cereal-based samples within the Italian Total Diet Study project. View Full-Text
Keywords: mycotoxin; aflatoxins; ochratoxin A; deoxynivalenol; fumonisins; T-2 and HT-2 toxins; zearalenone; Total Diet Study; liquid chromatography-tandem mass spectrometry mycotoxin; aflatoxins; ochratoxin A; deoxynivalenol; fumonisins; T-2 and HT-2 toxins; zearalenone; Total Diet Study; liquid chromatography-tandem mass spectrometry
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De Santis, B.; Debegnach, F.; Gregori, E.; Russo, S.; Marchegiani, F.; Moracci, G.; Brera, C. Development of a LC-MS/MS Method for the Multi-Mycotoxin Determination in Composite Cereal-Based Samples. Toxins 2017, 9, 169.

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