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Cancers 2018, 10(4), 121; https://doi.org/10.3390/cancers10040121

Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer

Institute of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
Current address: 10 Center Drive, Laboratory of Pathology, Room 3B56, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20814, USA.
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Received: 28 February 2018 / Revised: 8 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
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Abstract

The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting the activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated YAP/TAZ activities are frequently observed in various types of tumors. Emerging evidence suggests that the ubiquitin system plays an important role in regulating Hippo pathway activity. Deregulation of ubiquitin ligases and of deubiquitinating enzymes has been implicated in increased YAP/TAZ activity in cancer. In this article, we review recent insights into the ubiquitin-mediated regulation of the mammalian Hippo pathway, its deregulation in cancer, and possibilities for targeting the Hippo pathway through the ubiquitin system. View Full-Text
Keywords: Hippo pathway; ubiquitination; ubiquitin E3 ligase; deubiquitination; deubiquitinating enzymes; oncogenic transformation Hippo pathway; ubiquitination; ubiquitin E3 ligase; deubiquitination; deubiquitinating enzymes; oncogenic transformation
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Nguyen, T.H.; Kugler, J.-M. Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer. Cancers 2018, 10, 121.

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