Next Article in Journal
NF-kappaB in Lung Tumorigenesis
Next Article in Special Issue
Remodeling of Tumor Stroma and Response to Therapy
Previous Article in Journal
A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a
Previous Article in Special Issue
Discriminating Different Cancer Cells Using a Zebrafish in Vivo Assay
Article Menu

Export Article

Open AccessReview
Cancers 2011, 3(4), 4245-4257; doi:10.3390/cancers3044245

Stroma-Directed Molecular Targeted Therapy in Gastric Cancer

Department of Gastroenterology and Metabolism, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan
*
Author to whom correspondence should be addressed.
Received: 11 October 2011 / Revised: 22 November 2011 / Accepted: 30 November 2011 / Published: 8 December 2011
(This article belongs to the Special Issue Tumor Stroma)
View Full-Text   |   Download PDF [856 KB, uploaded 8 December 2011]   |  

Abstract

Recent studies in molecular and cellular biology have shown that tumor growth and metastasis are not determined by cancer cells alone, but also by a variety of stromal cells. Tumor stroma contains abundant extracellular matrix and several types of cells, including carcinoma-associated fibroblasts (CAFs), endothelial cells, pericytes and inflammatory cells including macrophages. In gastric cancer tissues, tumor cells express platelet-derived growth factor (PDGF)-B. Stromal cells, including CAFs, pericytes and lymphatic endothelial cells, express PDGF receptor (PDGFR)-β. Administration of PDGFR tyrosine kinase inhibitor significantly decreases stromal reaction, lymphatic vessel area and pericyte coverage of tumor microvessels. Administration of PDGFR tyrosine kinase inhibitor in combination with cytotoxic chemotherapeutic drug(s) impairs the progressive growth and metastasis of gastric cancer. Activated stroma might serve as a novel therapeutic target in cases of gastric cancer. View Full-Text
Keywords: gastric cancer; stroma; platelet-derived growth factor receptor (PDGFR); carcinoma-associated fibroblast (CAF) gastric cancer; stroma; platelet-derived growth factor receptor (PDGFR); carcinoma-associated fibroblast (CAF)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kitadai, Y.; Kodama, M.; Shinagawa, K. Stroma-Directed Molecular Targeted Therapy in Gastric Cancer. Cancers 2011, 3, 4245-4257.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top