Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Microcontainer Fabrication
2.2. Harvesting of Biodegradable Microcontainers
2.3. Ex Vivo Mucoadhesion Studies with Biodegradable Microcontainers
2.4. Degradation Study in Intestinal Medium
3. Results and Discussion
3.1. Fabrication of PLGA Microcontainers
3.2. Ex Vivo Mucoadhesion Study
3.3. In Vitro Degradation Study in Intestinal Medium
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Material | Amount [mg] | Compression Time [min] | Holding Temperature [°C] | Cooling Ramp [K/min] | Platen Pressure [bar] |
---|---|---|---|---|---|
PLGA 50:50 | 250 ± 20 | 30 | 90 | 20 | 20 |
PLGA 75:25 | 400 ± 200 | 30 | 105 | 20 | 20 |
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Abid, Z.; Dalskov Mosgaard, M.; Manfroni, G.; Singh Petersen, R.; Hagner Nielsen, L.; Müllertz, A.; Boisen, A.; Sylvest Keller, S. Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery. Polymers 2019, 11, 1828. https://doi.org/10.3390/polym11111828
Abid Z, Dalskov Mosgaard M, Manfroni G, Singh Petersen R, Hagner Nielsen L, Müllertz A, Boisen A, Sylvest Keller S. Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery. Polymers. 2019; 11(11):1828. https://doi.org/10.3390/polym11111828
Chicago/Turabian StyleAbid, Zarmeena, Mette Dalskov Mosgaard, Giorgio Manfroni, Ritika Singh Petersen, Line Hagner Nielsen, Anette Müllertz, Anja Boisen, and Stephan Sylvest Keller. 2019. "Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery" Polymers 11, no. 11: 1828. https://doi.org/10.3390/polym11111828