Polymers 2014, 6(5), 1350-1365; doi:10.3390/polym6051350
Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach
1
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey
2
Department of Analytical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey
*
Author to whom correspondence should be addressed.
Received: 27 January 2014 / Revised: 29 April 2014 / Accepted: 30 April 2014 / Published: 9 May 2014
(This article belongs to the Special Issue Natural Polymers 2014)
Abstract
The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect. View Full-TextKeywords:
sodium alginate; natural polymers; metoclopramide; transdermal film; antiemetic drug; terpenes
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
Share & Cite This Article
MDPI and ACS Style
Aktar, B.; Erdal, M.S.; Sagirli, O.; Güngör, S.; Özsoy, Y. Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach. Polymers 2014, 6, 1350-1365.
Related Articles
Article Metrics
Comments
[Return to top]
Polymers
EISSN 2073-4360
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert