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Cells 2012, 1(4), 699-710; doi:10.3390/cells1040699

High Mobility Group Box Protein-1 in Wound Repair

1,2,* , 1
1 Department of Sciences and Innovative Technology, (DiSIT), University of Piemonte Orientale "A. Avogadro", Viale Teresa Michel 11, Alessandria 15121, Italy 2 Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, Milan 20132, Italy 3 Department of Experimental Medicine (DIMES)-Biochemistry Section, Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, Genoa 1-16132, Italy
* Author to whom correspondence should be addressed.
Received: 10 August 2012 / Revised: 10 September 2012 / Accepted: 19 September 2012 / Published: 28 September 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
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High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage), but it also activates and recruits stem cells, boosting tissue repair. Here, we focus on the role of HMGB1 in physiological and pathological responses, the mechanisms by which it contributes to tissue repair and therapeutic strategies base on targeting HMGB1.
Keywords: HMGB1; alarmin; DAMP; tissue repair; wound cytokine HMGB1; alarmin; DAMP; tissue repair; wound cytokine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ranzato, E.; Martinotti, S.; Pedrazzi, M.; Patrone, M. High Mobility Group Box Protein-1 in Wound Repair. Cells 2012, 1, 699-710.

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