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Antibodies 2014, 3(1), 130-152; doi:10.3390/antib3010130

From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, France
EFS Auvergne-Loire, 42023 Saint-Etienne, France
Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, PRES Université de Lyon, 42270 Saint Priest en Jarez, France
Author to whom correspondence should be addressed.
Received: 30 October 2013 / Revised: 16 January 2014 / Accepted: 29 January 2014 / Published: 20 February 2014
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
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Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.
Keywords: transfusion; transplantation; alloimmunization; tolerance; HLA transfusion; transplantation; alloimmunization; tolerance; HLA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Prigent, A.; Maillard, N.; Absi, L.; Aloui, C.; Cognasse, F.; Laradi, S.; Mariat, C.; Garraud, O. From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization. Antibodies 2014, 3, 130-152.

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