A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens
Abstract
:1. Introduction
2. Results
2.1. Experiment 1: A High-Fat Meal Increases Extracellular NAc DA Levels More than a Less Palatable Low-Fat Meal
Experiment 1 | Baseline | 20 min | 40 min | 60 min |
DOPAC | ||||
High-Fat Meal | 99 ± 2% | 124 ± 4% | 125 ± 5% | 122 ± 7% |
Low-Fat Meal | 102 ± 1% | 113 ± 5% | 115 ± 5% | 112 ± 6% |
HVA | ||||
High-Fat Meal | 102 ± 3% | 117 ± 4% | 126 ± 4% | 130 ± 7% |
Low-Fat Meal | 100 ± 2% | 112 ± 5% | 119 ± 6% | 120 ± 6% |
Experiment 2 | Baseline | 60 min | 120 min | 180 min |
DOPAC | ||||
Intralipid | 99 ± 1% | 112 ± 7% | 100 ± 5% | 98 ± 3% |
Glucose | 97 ± 1% | 93 ± 5% | 86 ± 3% | 82 ± 6% |
Saline | 101 ± 2% | 94 ± 5% | 108 ± 12% | 103 ± 10% |
HVA | ||||
Intralipid | 99 ± 2% | 113 ± 8% | 103 ± 4% | 101 ± 5% |
Glucose | 98 ± 1% | 95 ± 6% | 90 ± 2% | 92 ± 3% |
Saline | 98 ± 3% | 97 ± 6% | 105 ± 8% | 103 ± 7% |
2.2. Experiment 2: Injection of Intralipid Increases Extracellular NAc DA Levels Compared to Glucose or Saline
2.3. Histology
3. Discussion
3.1. Role of Calories in Fat-Induced Increase in Extracellular Levels of NAc DA and Hyperphagia
3.2. Role of Palatability in Fat-Induced Increase in Extracellular NAc DA Levels and Hyperphagia
3.3. Role of Circulating Lipids in Fat-Induced Increases in Extracellular NAc DA Levels and Hyperphagia
4. Experimental Procedure
4.1. Subjects
4.2. Surgery
4.3. Microdialysis and DA Assays
4.4. Diets
4.5. Test Procedures
4.6. Histology
4.7. Data Analysis
5. Conclusion
Abbreviations
DA | dopamine |
DOPAC | 3,4-dihydroxyphenlyacetic acid |
HVA | homovanillic acid |
NAc | nucleus accumbens |
TG | triglycerides |
Acknowledgments
Conflict of Interest
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Rada, P.; Avena, N.M.; Barson, J.R.; Hoebel, B.G.; Leibowitz, S.F. A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens. Brain Sci. 2012, 2, 242-253. https://doi.org/10.3390/brainsci2020242
Rada P, Avena NM, Barson JR, Hoebel BG, Leibowitz SF. A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens. Brain Sciences. 2012; 2(2):242-253. https://doi.org/10.3390/brainsci2020242
Chicago/Turabian StyleRada, Pedro, Nicole M. Avena, Jessica R. Barson, Bartley G. Hoebel, and Sarah F. Leibowitz. 2012. "A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens" Brain Sciences 2, no. 2: 242-253. https://doi.org/10.3390/brainsci2020242