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Vaccines 2013, 1(2), 174-203; doi:10.3390/vaccines1020174

Tumor-Associated Glycans and Immune Surveillance

1
Winthrop P. Rockefeller Cancer Institute and Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Stephan Angeloff Institute of Microbiology, BAS, Sofia 1113, Bulgaria
*
Author to whom correspondence should be addressed.
Received: 18 April 2013 / Revised: 18 April 2013 / Accepted: 6 June 2013 / Published: 17 June 2013
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [680 KB, uploaded 17 June 2013]   |  

Abstract

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that bridge innate immune surveillance and adaptive antitumor immunity in clinical applications. T-cells, being a part of the adaptive immune response, are the most popular component of the immune system considered for targeting tumor cells. However, for TACAs, T-cells take a back seat to antibodies and natural killer cells as first-line innate defense mechanisms. Here, we briefly highlight the rationale associated with the relative importance of the immune surveillance machinery that might be applicable for developing therapeutics. View Full-Text
Keywords: monoclonal antibodies; immunotherapy; cancer; mimics; vaccine; TACA; glycans; tumor; carbohydrate monoclonal antibodies; immunotherapy; cancer; mimics; vaccine; TACA; glycans; tumor; carbohydrate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Monzavi-Karbassi, B.; Pashov, A.; Kieber-Emmons, T. Tumor-Associated Glycans and Immune Surveillance. Vaccines 2013, 1, 174-203.

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