Use of Tetravalent Galabiose for Inhibition of Streptococcus Suis Serotype 2 Infection in a Mouse Model
AbstractStreptococcus suis is an important swine pathogen associated with a variety of infections such as meningitis, arthritis and septicemia. The bacterium is zoonotic and has been found to cause meningitis especially in humans occupationally exposed to infected pigs. Since adhesion is a prerequisite for colonization and subsequent infection, anti-adhesion treatment seems a natural alternative to traditional treatment with antibiotics. In order to optimize the inhibitory potency a multivalency approach was taken in the inhibitor design. A synthetic tetravalent galabiose compound was chosen which had previously shown promising anti-adhesion effects with S. suis in vitro. The aim of this study was to evaluate the in vivo effects of the compound using an infection peritonitis mouse model. As such S. suis serotype 2 infection and treatment were tested in vivo and the effects were compared to the effect of treatment with penicillin.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Pieters, R.J.; Slotved, H.-C.; Mortensen, H.M.; Arler, L.; Finne, J.; Haataja, S.; Joosten, J.A.F.; Branderhorst, H.M.; Krogfelt, K.A. Use of Tetravalent Galabiose for Inhibition of Streptococcus Suis Serotype 2 Infection in a Mouse Model. Biology 2013, 2, 702-718.
Pieters RJ, Slotved H-C, Mortensen HM, Arler L, Finne J, Haataja S, Joosten JAF, Branderhorst HM, Krogfelt KA. Use of Tetravalent Galabiose for Inhibition of Streptococcus Suis Serotype 2 Infection in a Mouse Model. Biology. 2013; 2(2):702-718.Chicago/Turabian Style
Pieters, Roland J.; Slotved, Hans-Christian; Mortensen, Hanne M.; Arler, Lene; Finne, Jukka; Haataja, Sauli; Joosten, John A.F.; Branderhorst, Hilbert M.; Krogfelt, Karen A. 2013. "Use of Tetravalent Galabiose for Inhibition of Streptococcus Suis Serotype 2 Infection in a Mouse Model." Biology 2, no. 2: 702-718.