Table of Contents
Healthcare, Volume 5, Issue 3 (September 2017)
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Cover Story (view full-size image) Despite the fact that Alzheimer’s disease is the leading cause of dementia worldwide, there is no [...] Read more. Despite the fact that Alzheimer’s disease is the leading cause of dementia worldwide, there is no cure. Nonetheless, great advances have been made to elucidate its age-related, genetic, and environmental risk factors. The genetics include the outsized role played by the Aβ peptide and protein misfolding, while environmental risks include exposure to particulate air pollution. This review discusses what is known about the disease and proposes a hypothesis for the mechanistic link between its genetics and the environmental risk factors. A new hypothesis suggesting that poor air quality might act by disrupting protein-folding homeostasis (proteostasis) is presented. View this paper