In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cohort of Swine
2.2. Devices and Consumables
2.3. Protocol for EC-Ethanol Ablation and Thermocoagulation Procedures in Swine Cervix
2.4. Processing for Histopathological Assessment
2.5. Semi-Automated Image Processing Algorithms
2.6. Image Alignment and Volume Reconstruction
2.7. Statistical Analysis
2.8. Data Availability
3. Results
3.1. EC-Ethanol Ablation Achieved Comparable Acute Safety Endpoints to That of Thermocoagulation
3.2. EC-Ethanol Ablation Achieved Comparable Depth and Volume of Necrosis in the Upper Half of the Cervix as Compared to That of Thermocoagulation
3.3. EC Deposits Remain in Cervix for at Least 7 Days and Multiple EC-Ethanol Injections Can Induce Necrosis at Different Positions in the Cervix
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Quang, T.T.; Yang, J.; Kaluzienski, M.L.; Parrish, A.; Farooqui, A.; Katz, D.; Crouch, B.; Ramanujam, N.; Mueller, J.L. In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model. Bioengineering 2023, 10, 1246. https://doi.org/10.3390/bioengineering10111246
Quang TT, Yang J, Kaluzienski ML, Parrish A, Farooqui A, Katz D, Crouch B, Ramanujam N, Mueller JL. In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model. Bioengineering. 2023; 10(11):1246. https://doi.org/10.3390/bioengineering10111246
Chicago/Turabian StyleQuang, Tri T., Jeffrey Yang, Michele L. Kaluzienski, Anna Parrish, Asma Farooqui, David Katz, Brian Crouch, Nimmi Ramanujam, and Jenna L. Mueller. 2023. "In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model" Bioengineering 10, no. 11: 1246. https://doi.org/10.3390/bioengineering10111246