Bispidine-Based Macrocycles: Achievements and Perspectives
Abstract
:1. Introduction
2. Macrocycles with One Bispidine Fragment
2.1. Full-Amide Macrocycles
2.2. Mixed Amide-Amine Macrocycles
2.3. Full-Amine Macrocycles
3. Macrocycles with Two or More Bispidine Fragments
3.1. Full-Amide Macrocycles
3.2. Full-Amine Macrocycles
4. Concluding Remarks
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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m (for n = 1) | Catalyst’s Generation | Double Bond Configuration | Yield |
---|---|---|---|
2 | 1 | E | 53% |
3 | 1 | Z | 60% |
4 | 1 | Z:E = 2.6:1 | 51% |
2 | 2 | E | 80% |
3 | 2 | E | 79% |
4 | 2 | Z:E = 1.5:1 | 36% |
Cycle Size | Full Amine | Full Amide | Amino-Amide |
---|---|---|---|
10 | 10-NHN2CO | ||
11 | 11-N2H | 11-N2CO | |
13 | 13-N2H 13-N2HO2 | 13-N2CO | 13-N2HN2CO |
14 | 14-N4H 14-NHO3 * | 14-N2HN2CO | |
15 | 15-N2H 15-N2HO2 | 15-N2CO | |
16 | 16-N2HO3 | 16-N4COFe1 | |
18 | 18-N2HO3 | ||
19 | 19-N2HO4 19-N2HO4-38-O4-19-N2HO4 19-N2HO4-34-O4-19-N2HO4 | ||
20 | 20-N4CO 20-N4COFe2 | ||
21 | 21-N2HN2CO | ||
22 | 22-N2HO5 | 22-N2HN2CO | |
26 | 26-N4HO4 | ||
30 | 30-N6COFe3 | ||
32 | 32-N8CO | ||
34 | 34-N8CO | ||
50 | 50-N10COFe5 |
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Medved’ko, A.V.; Gaisen, S.V.; Kalinin, M.A.; Vatsadze, S.Z. Bispidine-Based Macrocycles: Achievements and Perspectives. Organics 2023, 4, 417-437. https://doi.org/10.3390/org4030030
Medved’ko AV, Gaisen SV, Kalinin MA, Vatsadze SZ. Bispidine-Based Macrocycles: Achievements and Perspectives. Organics. 2023; 4(3):417-437. https://doi.org/10.3390/org4030030
Chicago/Turabian StyleMedved’ko, Aleksei V., Savelii V. Gaisen, Mikhail A. Kalinin, and Sergey Z. Vatsadze. 2023. "Bispidine-Based Macrocycles: Achievements and Perspectives" Organics 4, no. 3: 417-437. https://doi.org/10.3390/org4030030