Antimicrobial Activity of Secondary Metabolites Produced in Nature
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 6147
Special Issue Editors
Interests: antimicrobial resistance; biofilm; multi-resistant bacteria; methicillin-resistant staphylococcus aureus; antibiotics; natural and synthetic antimicrobial compounds; plant extracts and essential oils; chalcones; anticancer activity; anti-inflammatory activity; cytotoxicity assays; in vivo animal models of autoimmune diseases, sepsis, and inflammation; one health; microbiological quality control of medicines; GMP
Special Issues, Collections and Topics in MDPI journals
Interests: bioactive phytochemicals; essential oils; plant extracts; phytochemistry; phytotherapy; composition, variability, and chemotaxonomic significance of essential oils; biological activity of herbal drugs; polyphenols; flavonoids; ethnopharmacology; antimicrobial activity; functional food
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) is a growing global burden that results in increased morbidity, mortality, and healthcare costs. According to the World Health Organization, AMR leads to an estimated 700,000 deaths worldwide each year, and this number is expected to rise to 10 million deaths per year by 2050 if action is not taken. Such a complex problem requires a multifaceted approach involving not only better antibiotic stewardship and improved infection prevention and control, but also the development of novel antimicrobial agents.
Secondary metabolites are very potent organic compounds synthesized by plants, fungi, and bacteria as a means of defense against predators, competitors, or pathogens. Some examples of secondary metabolites from nature include alkaloids, flavonoids, terpenoids, and phenolic compounds, which have a wide range of biological activities, such as antimicrobial, antifungal, antiviral, antiprotozoal, antioxidant, anticancer, and anti-inflammatory properties. These compounds have been used for centuries in traditional medicine and are also a rich source of new drug leads for the pharmaceutical industry. Many drugs used in modern medicine, such as artemisinin, morphine, codeine, and atropine are derived from plant secondary metabolites, others are very potent antibacterial agents derived from fungi, such as penicillin, or bacteria, such as streptomycin, nystatin, erythromycin, vancomycin, teicoplanin, etc.
The aim of this Special Issue is to bring together experts from different areas of microbiology, pharmacognosy, pharmacology, and medicinal chemistry to promote interdisciplinary collaborations and facilitate the translation of scientific discoveries into new therapies for patients, as well as for the veterinarian sector. Topics of interest include the antimicrobial effect of secondary metabolites on microorganisms; they are not limited only to the stasis of growth or cytocidal effect, and extend to the inhibition of microorganisms through modulation of virulence factors. We encourage original research articles (in vitro, in vivo, and in silico), case reports, observational studies, clinical trials, systematic reviews, meta-analyses, and perspectives that provide new insights into these topics, and that have the potential to impact the field.
Dr. Dragana Božić
Dr. Mirjana D. Marčetić
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antimicrobial resistance
- multidrug-resistant pathogens
- secondary metabolites
- natural products
- terpenes
- phenolic compounds
- polyketides
- antimicrobial peptides
- bacteriocins
- bacterial/fungal toxins
