PK/PD Models for Optimizing Antibiotic Use and Avoiding Drug-Drug Interaction

Dear Colleagues,

Optimizing antibiotic use is crucial in pharmacology as it allows for improving antimicrobial therapy while minimizing the development of resistance. Pharmacokinetic/pharmacodynamic (PK/PD) models are pivotal in understanding the relationship between drug exposure and desired therapeutic outcomes. By integrating pharmacokinetic parameters with pharmacodynamic endpoints, these models provide valuable insights into the dosing regimens and drug combinations that maximize antimicrobial efficacy. In addition, they can be essential for avoiding unwanted effects resulting from drug-drug interactions.

This Special Issue explores the various applications of PK/PD models in antibiotic optimization, showcasing the latest research findings, methodological advancements, and practical implications and highlighting potential interactions resulting from the simultaneous presence of antimicrobial therapy with other medications. Incorporating pharmacokinetic parameters (how drugs move within the body) and pharmacodynamic effects (how drugs interact with pathogens and other drugs) provides unique insights into antimicrobial dosing regimens, treatment strategies, and the development of new antibiotics. By delving into these areas, we hope to enhance our understanding of the underlying mechanisms driving antibiotic efficacy and resistance, ultimately informing clinical decision-making and improving patient outcomes.

Dr. Nahed El-Najjar
Dr. Takahisa Yano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• pharmacokinetics
• pharmacodynamics
• clinical outcome
• antimicrobial resistance
• antibiotic use
• drug-drug interaction