Antioxidant–Drug Interactions and Their Effects on Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 15 December 2024 | Viewed by 277
Special Issue Editors
Interests: sex-gender pharmacology; biomarkers; metabolism; cell signalling; autophagy and apoptosis
Special Issues, Collections and Topics in MDPI journals
Interests: stem cell biology; cell differentiation; cellular mechanisms; cell senescence; stress response; gene and protein expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress results from the combined effects of cellular energy failure, acidosis, hypoxia, hyperoxia, and inflammation, which lead to the increased generation of free radicals. Free radicals have been linked to a variety of diseases; therefore, the intake of substances with an antioxidant action appears useful in their prevention. It has been well established that complex mixtures of phytochemicals in fruits and vegetables can be beneficial for human health, preserving cells from premature senescence and counteracting the damages induced by reactive oxidative species (ROS). However, they can influence the pharmacological activity of drugs by modifying their pharmacokinetic characteristics via interactions with transporters and with the enzymatic systems that metabolize drugs. Drugs and foods can interact with each other: drugs can change nutritional status, body weight and nutrient availability, while some exogenous antioxidants can influence the effects and efficacy of drugs. Knowledge of these possible interactions is therefore essential to implement preventive therapies based on antioxidants in the presence of other pharmacological therapy, taking into consideration the individual characteristics of the subjects treated (sex, age, lifestyles and pathologies).
This Special Issue will be devoted to understanding the effects of antioxidants and their interactions with other drugs. It will contain up-to-date research and review articles addressing every aspect of molecular machinery to provide a cutting-edge overview of this fast-moving area.
Dr. Ilaria Campesi
Dr. Sara Cruciani
Guest Editors
Manuscript Submission Information
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Keywords
- oxidative stress
- antioxidants
- drug interaction
- cellular biology
- molecular biology
- sex-gender differences
- cell senescence
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