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Journals
Antioxidants
Special Issues
Oxidative Stress and Metals Metabolism
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Oxidative Stress and Metals Metabolism

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (30 September 2016) | Viewed by 41594

Special Issue Editors

Prof. Dr. Ananda S. Prasad

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Guest Editor
Department of Oncology, Wayne State University School of Medicine, 1122 Elliman Bldg., 421 East Canfield, Detroit, MI 48201, USA
Interests: zinc metabolism; copper and iron in humans
Dr. Bin Bao

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Guest Editor
Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA

Special Issue Information

Dear Colleagues,

Some metals, such as zinc, selenium, and magnesium, have antioxidant properties.  Metallothionein, a small molecular weight protein is very efficient in removing hydroxyl ions and, thus, is an important factor in decreasing oxidative stress. There are other metals, such as iron and copper, which upregulate generation of •OH and, thus, increase reactive oxygen species (ROS). We plan to cover these elements in our symposium.

Prof. Dr. Ananda S. Prasad
Dr. Bin Bao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • Oxidative stress
  • Inflammation
  • Antioxidants
  • Zinc
  • Copper
  • Iron
  • Selenium

Published Papers (2 papers)

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Review

509 KiB  
Review
Zinc and Oxidative Stress: Current Mechanisms
by Dilina Do Nascimento Marreiro, Kyria Jayanne Clímaco Cruz, Jennifer Beatriz Silva Morais, Jéssica Batista Beserra, Juliana Soares Severo and Ana Raquel Soares De Oliveira
Antioxidants 2017, 6(2), 24; https://doi.org/10.3390/antiox6020024 - 29 Mar 2017
Cited by 345 | Viewed by 30140
Abstract
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human [...] Read more.
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases. Full article
(This article belongs to the Special Issue Oxidative Stress and Metals Metabolism)
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1734 KiB  
Review
The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution
by Yuta Hatori and Svetlana Lutsenko
Antioxidants 2016, 5(3), 25; https://doi.org/10.3390/antiox5030025 - 27 Jul 2016
Cited by 93 | Viewed by 10934
Abstract
Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. This process is required for activation of copper dependent enzymes involved in neurotransmitter [...] Read more.
Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. This process is required for activation of copper dependent enzymes involved in neurotransmitter biosynthesis, iron efflux, neovascularization, wound healing, and regulation of blood pressure. Recently, new cellular roles for Atox1 have emerged. Changing levels of Atox1 were shown to modulate response to cancer therapies, contribute to inflammatory response, and protect cells against various oxidative stresses. It has also become apparent that the activity of Atox1 is tightly linked to the cellular redox status. In this review, we summarize biochemical information related to a dual role of Atox1 as a copper chaperone and an antioxidant. We discuss how these two activities could be linked and contribute to establishing the intracellular copper balance and functional identity of cells during differentiation. Full article
(This article belongs to the Special Issue Oxidative Stress and Metals Metabolism)
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