Recent Progress and Challenges of Artificial Intelligence in Bioinformatics and New Medicine
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 5609
Special Issue Editors
Interests: bioinformatics; machine learning; network modeling; deep learning; big data mining
Interests: machine learning; network modeling; deep learning
Special Issue Information
Dear Colleagues,
At present, big data in biology, medical science, and public health are expanding rapidly, accelerating the development of new medicine. Discoveries in novel life sciences and translational medicine are constantly being promoted by the accumulation of big data. A number of disruptive new technologies, new methods, and new tools in the field of life and health have been formulated, and these are rapidly becoming a scientific and technological strategic focus leading the future of the life sciences, medical and health industries, and economic and social development. The cross-border integration and cross-innovation of the life sciences, medicine, and information science are the engines that push new medicine forward. In particular, advances in artificial intelligence (AI) have been applied in bioinformatics and new medicine, leading to tremendously successful novel discoveries. However, this process is accompanied by a lot of challenges, such as complex data modalities, the integration of multi-omics, highly dimensional features with a small sample size, etc. Considering these aspects, specific artificial intelligence methods are needed to handle the challenges in the field of bioinformatics and new medicine.
The aim of this Research Topic is to showcase advanced artificial intelligence methods and the traditional bioinformatics, data mining and statistical approaches helpful to discover novel knowledge in life science and new medicine. Topics of interest include, but are not limited to:
- Review articles about the recent progress and challenges related to AI methods in bioinformatics and medical science.
- Integration of single-cell omics.
- Discovering novel knowledge in cancers and other complex diseases.
- Exploration of risk factors of complex diseases.
- Databases and webservers in bioinformatics.
- Tumor heterogeneity and microenvironment.
- Deep learning methods in bioinformatics and medical science.
- Network modeling and analysis.
Dr. Tao Wang
Dr. Jiajie Peng
Dr. Yongtian Wang
Guest Editors
Manuscript Submission Information
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Keywords
- artificial intelligence
- bioinformatics
- deep learning
- new medicine
- cancer
- single cell omics
- network
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Blockchain Technology for Advanced Therapy Medicinal Products: Applications in Tracking, Data Sharing, and Supply Chain Automation
Authors: Cristobal Aguilar-Gallardo; Ana Bonora-Centelles
Affiliation: Unidad de Terapias Avanzadas. Instituto Investigación Sanitaria La Fe. Av. Fernando Abril Martorell, 106. 46026 Valencia-Spain
Abstract: Advanced therapy medicinal products (ATMPs) like cell and gene therapies offer transformative treatment options for many diseases. However, coordinating the decentralized, patient-specific manufacturing of autologous ATMPs across multiple hospitals poses major supply chain challenges. This paper provides a comprehensive analysis of how blockchain technology can enhance decentralized ATMP manufacturing networks. First, background on ATMPs and complexities of decentralized production is reviewed. An overview of blockchain architecture, key attributes, and existing use cases then follows. The major opportunities for blockchain integration in ATMP manufacturing are discussed in depth, including tracking autologous products across locations, enabling data sharing between hospitals to power AI-based optimization, automating supply chain processes, and maintaining provenance records. Critical limitations around scalability, privacy, regulation, and adoption barriers are examined. Design considerations for developing blockchain ecosystems tailored to the unique ATMP environment are also explored. Blockchain shows immense promise for transforming visibility, coordination, automation, and data unification in decentralized ATMP manufacturing networks. Despite current challenges, blockchain is prepared to profoundly impact the advancement of personalized cell and gene therapies through enhanced supply chain instrumentation. This paper provides a comprehensive analysis of this emerging technological innovation and its applications to address critical needs in ATMP translation and manufacturing.