Applied Sciences

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Special Issue Information

Dear Colleagues,

Bioreactors are a vital tool in bioprocessing, providing a controlled environment for the growth of living cells of microorganisms, plants and fungi, thus enabling efficient and precise bioprocessing. The utilization of bioreactors leads to the establishment of effective control parameters for cell growth and valuable secondary metabolite biosynthesis. Utilizing culture in a bioreactor may also be a crucial step in the production of biomass and valuable natural compounds, from a laboratory to a semi-industrial and even industrial-scale process. Therefore, this Special Issue aims to present new data and experimental results both in the field of new bioreactor systems/prototypes, as well as known constructions used for novel, scientifically unexplored species of microorganisms, fungi and plants; this is particularly with regard to the production of high-efficiency biomass and the biosynthesis of valuable natural compounds . This Special Issue will publish high-quality, original scientific papers that provide new data on bioreactor cultures with a focus on novel, more efficient scalable bioprocessing systems.

Prof. Dr. Łukasz Kuźma
Guest Editor

Manuscript Submission Information

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Keywords

natural compounds
bioreactor cultures
quantitative determination of the natural products
biotechnological investigations

Published Papers (2 papers)

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Research

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14 pages, 1118 KiB

Open AccessArticle

Use of Bayesian Methods in the Process of Uranium Bioleaching by Acidithiobacillus ferrooxidans

by Altair Costa Cardoso, Camila Santana Dias, Carlos Henrique Rodrigues de Moura, Josiel Lobato Ferreira, Emerson Cardoso Rodrigues, Emanuel Negrão Macêdo, Diego Cardoso Estumano and Bruno Marques Viegas

Appl. Sci. 2024, 14(1), 109; https://doi.org/10.3390/app14010109 - 22 Dec 2023

Viewed by 781

Abstract

This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching process by Acidithiobacillus ferrooxidans. Experimental data of cell concentration, uranium concentration, and concentrations of ferrous and ferric ions, obtained from literature, were employed. These measurements were evaluated using a mathematical model expressed by a system of ordinary differential equations. Three different mathematical models were evaluated, considering different uncertainties in experimental measurements and mathematical models (1% and 5%). The estimation results presented a good fit to the experimental data, with coefficients of determination in the range of 0.95 to 0.99. The validation of the mathematical models was obtained by reproducing the experimental measurements and the Bayesian techniques proved to be suitable for application in the bioleaching process. Full article

(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)

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Review

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22 pages, 633 KiB

Open AccessReview

Exploring Key Parameters in Adsorption for Effective Fluoride Removal: A Comprehensive Review and Engineering Implications

by Letícia Reggiane de Carvalho Costa, Ivone Vanessa Jurado-Davila, Júlia Toffoli De Oliveira, Keila Guerra Pacheco Nunes, Diego Cardoso Estumano, Robson Alves de Oliveira, Elvis Carissimi and Liliana Amaral Féris

Appl. Sci. 2024, 14(5), 2161; https://doi.org/10.3390/app14052161 - 05 Mar 2024

Viewed by 813

Abstract

Water pollution, particularly from elevated fluoride ion (F⁻) concentrations, is a significant challenge in many developing countries, particularly those relying on groundwater. The stable form of fluoride, F⁻, poses health risks, leading to concerns about various diseases and harmful effects. Despite global efforts, high F⁻ concentrations (>1.5 mg L⁻¹) persist in numerous countries, requiring effective and sustainable removal methods. Adsorption, known for its simplicity, cost-effectiveness, and efficiency, stands out as a promising technique for F⁻ removal from drinking water. Successful commercial implementation necessitates the optimization of separation conditions. This systematic literature review focuses on the adsorption process for F⁻ removal, exploring parameters such as temperature, adsorbent particle size, pH, adsorbent mass, and co-existing ions for efficient removal. Observations indicate that, despite the utilization of a diverse range of adsorbents, several limitations persist. These include low adsorption capacity, a sluggish adsorption rate, a restricted pH range, and high associated costs. The mechanistic understanding of adsorption and the ongoing development of novel adsorbents remain focal points for future research. Additionally, there is a need to explore alternative kinetic models grounded in statistical factors and give due consideration to thermodynamic studies. Full article

(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)

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