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Applied Sciences
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Nanomaterials in Medical Diagnosis and Therapy
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Nanomaterials in Medical Diagnosis and Therapy

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 2215

Special Issue Editors

Dr. Francesca Brero

E-Mail Website
Guest Editor
National Institute for Nuclear Physics, 27100 Pavia, Italy
Interests: magnetic nanoparticles; NMR; MRI; radiomics; machine learning; magnetic fluid hyperthermia
Special Issues, Collections and Topics in MDPI journals
Dr. Manuel Mariani

E-Mail Website
Guest Editor
Department of Physics, University of Pavia, 27100 Pavia, Italy
Interests: magnetic nanoparticles; NMR; MRI; molecular magnetism; magnetic fluid hyperthermia

Special Issue Information

Dear Colleagues,

We invite you to contribute to this Special Issue entitled “Nanomaterials in Medical Diagnosis and Therapy”. Starting from the new millennium, the interest in the study of nanostructured materials has progressively increased with the ability to manipulate matter at the nanoscale. This has paved the way to the creation of a plethora of novel systems characterized by extremely appealing properties exploitable in a wide number of clinical theranostic applications. For this purpose, synergetic efforts deriving from the exchange among different expertise in different branches of science such as physics, chemistry, biology, engineering, and medicine are fundamental. Thus, this Special Issue addresses original research papers or review articles related to synthesis, (magnetic) characterization, and theoretical interpretation of the features of nanomaterials to improve diagnostic performance and optimize treatment strategies.

Researchers are invited to submit manuscripts on these crucial topics, highlighting the importance of new nanomaterials in improving the diagnosis, the treatment, and the monitoring of diseases with the possible final aim of their translation to clinics.

Dr. Francesca Brero
Dr. Manuel Mariani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanoparticles
  • theranostics
  • diagnosis
  • cancer therapy
  • synthesis and characterization
  • health sciences
  • drug delivery
  • functionalization
  • biocompatibility

Published Papers (2 papers)

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Research

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18 pages, 2437 KiB  
Article
The Influence of Ionizing Radiation on Paclitaxel-Loaded Nanoparticles Based on PLGA
by Izabela M. Domańska, Ramona Figat, Aldona Zalewska, Krystyna Cieśla, Sebastian Kowalczyk, Karolina Kędra and Marcin Sobczak
Appl. Sci. 2023, 13(19), 11052; https://doi.org/10.3390/app131911052 - 07 Oct 2023
Viewed by 850
Abstract
The effect of ionizing radiation (γ-rays and electron beam) on anticancer drug delivery systems (DDSs) properties was evaluated concerning potential sterilization. For this purpose, paclitaxel (PTX)-loaded nanoparticles were obtained using a biodegradable, self-developed copolymer of l-lactide and glycolide (PLGA), synthesized in the [...] Read more.
The effect of ionizing radiation (γ-rays and electron beam) on anticancer drug delivery systems (DDSs) properties was evaluated concerning potential sterilization. For this purpose, paclitaxel (PTX)-loaded nanoparticles were obtained using a biodegradable, self-developed copolymer of l-lactide and glycolide (PLGA), synthesized in the presence of bismuth 2-ethylhexanoate catalyst. The nanoparticles were obtained with a high encapsulation efficiency of PTX (EE = 94.2%). The average size of the nanoparticles was 253.5 nm. The influence of irradiation (sterilization dose, 25 kGy) on the microstructure and the physicochemical and thermal properties of the polymer matrix was investigated, as well as the effect of irradiation on the morphology and physicochemical properties of the pharmaceutical formulations of the nanoparticles. Additionally, an in vitro drug release study was conducted regarding any alterations in the kinetic profiles of drug release. It was confirmed that the irradiation with both types of ionizing radiation, i.e., γ-rays and electron-beam (EB), slightly decreased the average molecular weight of the polymer matrix. While only negligible changes in the microstructure and thermal properties of PLGA were observed after irradiation with EB, the average length of lactidyl blocks (lLL) in the copolymer chains irradiated with γ-rays decreased from 4.33 to 3.35. Moreover, the contribution of crystalline phase (Xc) in γ-irradiated samples decreased significantly from 35.1% to 22.7%, suggesting a dominant mechanism of chain scission over cross-linking in PLGA samples irradiated with γ-rays. In vitro drug release results demonstrate a sustained and controlled release of PTX from the nanoparticles based on PLGA. The kinetics of drug release was defined as first order with non-Fickian diffusion. Only negligible differences in the kinetic profiles of PTX release from PLGA drug carriers were observed after irradiation. The overall results suggest good resistance of PLGA nanoparticles to irradiation within the conditions used and the great potential of EB in the sterilization process of the polymeric DDSs. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Diagnosis and Therapy)
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Review

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42 pages, 8878 KiB  
Review
Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery
by Joanna Kurczewska and Bernadeta Dobosz
Appl. Sci. 2024, 14(3), 1132; https://doi.org/10.3390/app14031132 - 29 Jan 2024
Viewed by 883
Abstract
Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over the years, the ability to synthesize diverse systems based on iron (II, III) oxide nanoparticles has been mastered to maximize their potential effectiveness in the targeted [...] Read more.
Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over the years, the ability to synthesize diverse systems based on iron (II, III) oxide nanoparticles has been mastered to maximize their potential effectiveness in the targeted delivery of active substances in cancer therapy. The present review explores recent literature findings that detail various magnetic nanosystems. These encompass straightforward designs featuring a polymer coating on the magnetic core and more intricate matrices for delivering chemotherapeutic drugs. This paper emphasizes novel synthetic approaches that impact the efficacy and progress of anticancer investigations, specifically targeting a particular cancer type. The research also delves into combinations with alternative treatment methods and diagnostic approaches. Additionally, it highlights a critical aspect—the interaction with cells—identifying it as the least developed aspect in current research on these systems. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Diagnosis and Therapy)
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