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Applied Sciences
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Advances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine
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Advances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 8457

Special Issue Editors

Dr. Raffaella Pecci

E-Mail Website1 Website2
Guest Editor
National Centre of Innovative Technologies in Public Health, Istituto Superiore di Sanità, Rome, Italy
Interests: biomechanical engineering; bioengineering; biomedical engineering; materials engineering; materials and devices testing; regulatory; micro-computed tomography; implantable medical devices; bone; bone substitutes; regenerative medicine; biomechanics; orthopedics; dentistry; maxillofacial surgery
Dr. Ilaria Campioni

E-Mail Website1 Website2
Guest Editor
Independent Researcher, Rome, Italy
Interests: biomedical engineering; biomechanical engineering; bioengineering; healthcare innovations; regulatory; materials and devices testing; quality controls; designs; 3D modeling; manufacturing technologies; additive manufacturing; finite element analysis; micro-computed tomography; implantable medical devices; prosthesis; biomaterials; bone; bone substitutes; regenerative medicine; orthopedics; dentistry; maxillofacial surgery
Prof. Dr. Antonio Scarano

E-Mail Website
Guest Editor
Post-Graduate School of Oral Surgery, University of Chieti-Pescara, 66100 Chieti, Italy
Interests: SARS-CoV-2; COVID-19; oral diseases; vaccines
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Mangione

E-Mail Website1 Website2 Website3 Website4 Website5 Website6 Website7
Guest Editor
1. UR 2496 Laboratory Orofacial Pathologies, Imaging and Biotherapies, Faculty of Dentistry and Life imaging Platform (PIV), University of Paris, Montrouge, France
2. AP-HP, Department of Dentistry, University Hospital Henri Mondor, Creteil, France
Interests: dentomaxillofacial imaging; microCT; CBCT; stem/progenitor cell therapy; regenerative medicine; tissue engineering; oral surgery; dental implant

Special Issue Information

Dear Colleagues,

This Special Issue invites papers that cover original research on advances in applied biomaterials and regenerative medicine for innovative biomedical applications as well as for improving the state of knowledge related to evidence that can be applied in the design, characterization, and evaluation of critical aspects.

Potential topics include but are not limited to applications in dentistry, odontostomatology, orthopedics, and maxillofacial surgery. Both in vitro and in/ex vivo studies involving clinical research, new methodologies and technologies for the experimental investigation and evaluation of advanced manufacturing processes (i.e., digital manufacturing, additive manufacturing, 3D printing, bioprinting, etc.) and prototypes, and the optimization of clinical and technical procedures, including based on computational and numerical models, will be considered. Furthermore, this issue will take into consideration research studies assessing quality, critical regulatory, ethical, and forensic medicine issues related to biomaterials, regenerative medicine, and the final applications of medical devices. Specific innovative methodologies for the manufacturing and assessment of personalized medical applications as well as the elaboration of data and images based on advanced analyses and approaches will also be included.

This Special Issue will comprise articles and review studies on relevant trends related to the main topics.

Dr. Raffaella Pecci
Dr. Ilaria Campioni
Prof. Dr. Antonio Scarano
Dr. Francesca Mangione
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • regenerative medicine
  • clinical and in vitro research
  • medical devices
  • advanced manufacturing
  • quality and regulatory
  • orthopedics
  • dentistry
  • maxillofacial surgery

Published Papers (3 papers)

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Research

11 pages, 1861 KiB  
Article
3D Printing Applications in Orthopaedic Surgery: Clinical Experience and Opportunities
by Andrea Fidanza, Tullio Perinetti, Giandomenico Logroscino and Michela Saracco
Appl. Sci. 2022, 12(7), 3245; https://doi.org/10.3390/app12073245 - 23 Mar 2022
Cited by 7 | Viewed by 2487
Abstract
Background: Three-dimensional (3D) printing is a technology capable of creating solid objects based on the reproduction of computerised images. This technology offers revolutionary impacts on surgical practice, especially in prosthetic and traumatological surgery. Methods: 20 patients with proximal humeral fractures were divided into [...] Read more.
Background: Three-dimensional (3D) printing is a technology capable of creating solid objects based on the reproduction of computerised images. This technology offers revolutionary impacts on surgical practice, especially in prosthetic and traumatological surgery. Methods: 20 patients with proximal humeral fractures were divided into two groups, one of which involved the processing of a 3D model. The model made it possible to plan the positioning and dimensions of the implants. The results were then compared with those obtained according to the usual procedures. We also reported the irreparable case of a custom revision implants acetabular bone loss treated with a 3D-printed, custom-made implant. Results: In the processed 3D proximal humeral fracture series, in the face of time and costs expenses, surgical and X-ray times were shorter than in the control group. On the other hand, there were no differences in terms of blood loss. The patient who underwent acetabular re-prosthetic surgery in a 3B Paprosky bone loss was managed and solved with a 3D-printed, custom-made implant and reported excellent outcomes at a 1 year follow-up. Conclusion: Three-dimensional printing made it possible to create better pre-operative planning in traumatology in order to optimise surgical procedures and outcomes. It also made it possible to deal with large losses of bone stock in prosthetic revision surgery, even when reconstruction may have appeared impossible with traditional implants. Full article
(This article belongs to the Special Issue Advances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine)
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12 pages, 6944 KiB  
Article
Silk Fibroin Scaffolds as Biomaterials for 3D Mesenchymal Stromal Cells Cultures
by Luisa Milazzo, Francesca Vulcano, Giampiero Macioce, Giovanna Marziali, Francesca Iosi, Lucia Bertuccini, Mario Falchi, Francesco Rech, Adele Giampaolo, Raffaella Pecci, Ilaria Campioni and Rossella Bedini
Appl. Sci. 2021, 11(23), 11345; https://doi.org/10.3390/app112311345 - 30 Nov 2021
Cited by 2 | Viewed by 2296
Abstract
Silk fibroin (SF), a protein-based fiber extracted from Bombyx mori cocoons, has recently emerged with great potential for the biomedical field to be used as a biomaterial processable in a variety of formats and applications, due to its natural characteristics. The aims of [...] Read more.
Silk fibroin (SF), a protein-based fiber extracted from Bombyx mori cocoons, has recently emerged with great potential for the biomedical field to be used as a biomaterial processable in a variety of formats and applications, due to its natural characteristics. The aims of the present study were to characterize the structural properties of the SF scaffolds, in the format of porous sponges, and to investigate their feasibility to support the adhesion of mesenchymal stromal/stem cells isolated from human Wharton’s jelly of the umbilical cord (WJ-MSC). Adhesion is a prerequisite for using the SF scaffold as biomaterial for supporting three-dimensional (3D) WJ-MSC cultures for several applications. The integration among micro-computed tomography, confocal analysis, and field emission scanning electron microscopy allowed carrying out a deep investigation based on quantitative morphological parameters and qualitative observations at high resolution. High levels of porosity, interconnection, and contact surface–volume ratio confirmed the appropriateness of the designed SF porous scaffolds as supports for cell cultures. WJ-MSC was demonstrated to be capable of adhering to and colonizing the SF scaffold applicable as a 3D cell culture system, of conducting in vitro experiments in a more controlled environment, and possibly of being used in tissue engineering, regenerative medicine, and applications in oncology. Full article
(This article belongs to the Special Issue Advances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine)
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14 pages, 34939 KiB  
Article
Design and Development of Magnesium-Based Suture Anchor for Rotator Cuff Repair Using Finite Element Analysis and In Vitro Testing
by Ting-Yu Su, Hao-Yuan Tang, Jason Shian-Ching Jang, Chih-Hwa Chen and Hsiang-Ho Chen
Appl. Sci. 2021, 11(20), 9602; https://doi.org/10.3390/app11209602 - 15 Oct 2021
Cited by 4 | Viewed by 2263
Abstract
A suture anchor is a medical device commonly used in rotator cuff repair surgery to attach tendons to the greater tuberosity of the humerus. Patient- and device-related factors, such as structural designs and poor bone density, can cause unsatisfactory clinical results. In this [...] Read more.
A suture anchor is a medical device commonly used in rotator cuff repair surgery to attach tendons to the greater tuberosity of the humerus. Patient- and device-related factors, such as structural designs and poor bone density, can cause unsatisfactory clinical results. In this study, a new suture anchor design with four distinctive parameters was proposed, and the structural performance was optimized in a full factorial experimental design using finite element analysis. Two types of bone blocks—normal and osteoporotic bone—which received screw implants, were simulated to investigate the parametrical effects on various bone qualities. The prescribed motion at a constant removal velocity was used to evaluate the pullout strength. The von Mises criterion was employed in a force control simulation for topology optimization. Moreover, mechanical tests guided by ASTM-F543-17 were conducted for validation. This paper demonstrates the comprehensive process for developing a suture anchor with sufficient mechanical integrity for clinical use and clarifies the contributions of each distinctive design parameter in this application. Full article
(This article belongs to the Special Issue Advances in Biomedical Applications: Biomaterials, Medical Devices and Regenerative Medicine)
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