Prof. Dr. Silvia Parisi
Prof. Dr. Silvia Parisi
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Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy
Interests: pluripotent stem cells; gene expression regulation; disease modelling; chromatin organization; RNA binding protein
Dr. Paul Wieringa
Dr. Paul Wieringa
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Institute for Technology-Inspired Regenerative Medicine (MERLN)/FHML, Maastricht University, Universiteitssingel 40, 6229 ET Maastricht, The Netherlands
Interests: neural engineering; 3D in vitro platforms; biomedical sciences
Dr. Massimiliano Caiazzo
Dr. Massimiliano Caiazzo
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Department of Molecular Medicine and Medical Biotechnology, University of Naples, “Federico II”, Via Pansini 5, 80131 Naples, Italy
Interests: cell reprogramming; disease modeling
Dr. Fabiana Passaro
Dr. Fabiana Passaro
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Guest Editor
University of Naples, “Federico II”, Naples, Italy
Interests: regenerative medicine; cardiac regeneration; direct reprogramming; molecular biology of regeneration
Dear Colleagues,
The derivation of embryonic stem cells (ESC), followed by the generation of induced pluripotent stem cells (iPSC) and the possibility of changing the identity of a somatic cell to another type of somatic cell through cell reprogramming, has profoundly changed developmental biology, as well as biomedical research. First, the use of pluripotent stem cells (PSCs), both ESCs and iPSCs, is fundamental for studying molecular mechanisms underlying embryo development, and this is particularly relevant if we use human iPSC differentiation to acquire knowledge on human development. Second, human PSCs, as well as direct reprogramming, hold tremendous potential for disease modeling, drug discovery, predictive toxicology, and regenerative medicine applications, providing access to cell types that are otherwise impossible to acquire. However, to properly use these powerful systems for all these aims, we need profound and complete knowledge of the mechanisms that allow cell reprogramming and guide PSC fate. Moreover, it is necessary to increasingly develop precise and reproducible methods, and to govern the reprogramming and/or the differentiation toward a specific cell fate. The use of biomaterials, as well as organ-on-chip and bio-printing approaches, can really make the difference in generating physiological and pathological tissue models in vitro.
This Special Issue aims to cover recent progresses done in understanding cell reprogramming, PSC differentiation and the use of PSCs, to model tissue physiology and pathology. We will especially focus on recently developed approaches, such as organ-on-chip and organoids that allow a better understanding of tissue function, organization, etc., beyond the single cell level.
We welcome the submission of original research, short communications, and review manuscripts focusing on methods which improve cell reprogramming and the differentiation of PSCs, as well as tissue modelling. Other important aspects that we would like to point out in this Special Issue are the molecular mechanisms that guide cell reprogramming and cell differentiation from PSCs, and those factors that limit the efficiency of these processes.
Prof. Dr. Silvia Parisi
Dr. Paul Wieringa
Dr. Massimiliano Caiazzo
Dr. Fabiana Passaro
Guest Editors
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