Nrf2 at the Crossroads of Molecular Mechanisms in Health and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1610
Special Issue Editors
Interests: oxidative stress; redox balance; antioxidants; athersoclersois; inflammation
Interests: chronic disorder; chronic kidney disease; obesity; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) has been studied extensively in recent years, and is primarily associated with the regulation of the redox balance in the body. It is a specific cellular transmitter of signals, stimulated by a number of factors related to oxidative stress and inflammation. Under certain conditions, the consequence of its induction is the transcription of a broad group of antioxidant compounds. The involvement of the NRF2 signaling pathway in the development of inflammation is not entirely clear. Recent studies report that the chronic activation of the NRF2 pathway may contribute to the development of reductive stress and intensify the inflammatory process, resulting in disease progression. In order to build a pharmacological therapy based on the activation of NRF2, let us try to explain the consequence of its overexpression in both health and disease. Let us find answers to the questions asking how we might stimulate/induce the NRF2 pathway so as not to lead to the harmful dysregulation of the redox system in the body.
The idea behind this Special Issue is therefore to assemble papers exploring the ups and downs of the NRF2 signaling pathway, both in physiological conditions and in disease.
Dr. Magdalena Paulina Kasprzak
Prof. Dr. Dorota Formanowicz
Guest Editors
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Keywords
- NRF2
- reductive stress
- overexpression
- oxidative stress
- Keap1
- antioxidants
