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Biomedicines
Special Issues
Nanomaterial-Based Contrast Agents for Biomedical Imaging
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Nanomaterial-Based Contrast Agents for Biomedical Imaging

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2707

Special Issue Editors

Dr. Bing Guo

E-Mail Website
Guest Editor
School of Science, Harbin Institute of Technology, Shenzhen 518055, China
Interests: polymer chemistry; molecular imaging probes; nanomedicines; prodrugs; aggregation-induced emission; fluorescence imaging; photoacoustic imaging; microscopy; wide-field imaging; two photon imaging; second harmonic imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Tingting Peng

E-Mail Website
Guest Editor
College of Pharmacy, Jinan University, Guangzhou, China
Interests: microneedles; microparticles; nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision imaging is critical for the theranostics of diseases, as it provides insightful guidance for medical personnel to define pathological processes and manage diseases. Nowadays, nanomaterials have emerged as promising alternatives to conventional contrast agents for biomedical imaging since they offer high-fidelity imaging due to an improved delivery efficiency and accumulation in the diseased tissues. With the assistance of advanced imaging techniques, these nanomaterials could provide diverse imaging modalities, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, micro-CT imaging, X-ray imaging, etc. More attractively, they could also be used as therapeutic agents to assist with therapy by harnessing the optical, acoustic, magnetic, and chemodynamic energies and converting them into therapeutic output. The theranostic performance of nanomaterials could be improved through the delicate tuning of the target ability, responsive release behavior, quantum yield, etc. Therefore, nanomaterials hold great promise for precision theranostics of diseases.

This Special Issue aims to highlight the recent advances in the development of nanomaterials for contrast agents and biomedical imaging. Original research papers and reviews papers are all welcome.

Dr. Bing Guo
Dr. Tingting Peng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial
  • contrast agent
  • theranostic agents
  • imaging techniques
  • diseases

Published Papers (2 papers)

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Research

12 pages, 25681 KiB  
Article
A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro
by Jiapeng Deng, Qichang Wang, Huihui Xu, Guoqing Li, Su Liu, Yixiao Chen, Fei Yu, Weiqiang Yan, Hui Zeng and Peng Liu
Biomedicines 2023, 11(6), 1524; https://doi.org/10.3390/biomedicines11061524 - 25 May 2023
Viewed by 1055
Abstract
Osteosarcoma is an aggressive malignant neoplasm, and it is of great significance to the fabrication and investigation of the anti-tumor mechanism of nanomedicine in the treatment of osteosarcoma. Herein, a cinnamaldehyde polymeric prodrug micelle with pH-sensitive charge-conversion ability (mPEG-b-P(C7-co-CA)) [...] Read more.
Osteosarcoma is an aggressive malignant neoplasm, and it is of great significance to the fabrication and investigation of the anti-tumor mechanism of nanomedicine in the treatment of osteosarcoma. Herein, a cinnamaldehyde polymeric prodrug micelle with pH-sensitive charge-conversion ability (mPEG-b-P(C7-co-CA)) was fabricated, and the anti-osteosarcoma mechanism of mPEG-b-P(C7-co-CA) micelle was investigated. mPEG-b-P(C7-co-CA) micelles were prepared by self-assembly method, and their diameter was 227 nm. mPEG-b-P(C7-co-CA) micelles could regulate the cell cycle and inhibit the proliferation of 143B cells, which was demonstrated by flow cytometry analysis, CCK-8 assay and 5-Ethynyl-2′-deoxyuridine (EdU) staining. The wound-healing assay and transwell assay showed that mPEG-b-P(C7-co-CA) micelles effectively inhibited the migration and invasion of 143B cells. It was proven that mPEG-b-P(C7-co-CA) micelles downregulated the levels of proliferation and apoptosis-related proteins and affected osteosarcoma migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT). In addition, mPEG-b-P(C7-co-CA) micelles can also inhibit the transcriptional activity of the PI3K/Akt signaling pathway. Therefore, these findings provide new evidence for the pharmacological effects of mPEG-b-P(C7-co-CA) micelles. Full article
(This article belongs to the Special Issue Nanomaterial-Based Contrast Agents for Biomedical Imaging)
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16 pages, 3578 KiB  
Article
Polyelectrolyte Coating of Ferumoxytol Differentially Impacts the Labeling of Inflammatory and Steady-State Dendritic Cell Subtypes
by Nehar Celikkin, John E. Wong, Martin Zenke and Thomas Hieronymus
Biomedicines 2022, 10(12), 3137; https://doi.org/10.3390/biomedicines10123137 - 05 Dec 2022
Cited by 2 | Viewed by 1111
Abstract
Engineered magnetic nanoparticles (MNPs) are emerging as advanced tools for medical applications. The coating of MNPs using polyelectrolytes (PEs) is a versatile means to tailor MNP properties and is used to optimize MNP functionality. Dendritic cells (DCs) are critical regulators of adaptive immune [...] Read more.
Engineered magnetic nanoparticles (MNPs) are emerging as advanced tools for medical applications. The coating of MNPs using polyelectrolytes (PEs) is a versatile means to tailor MNP properties and is used to optimize MNP functionality. Dendritic cells (DCs) are critical regulators of adaptive immune responses. Functionally distinct DC subsets exist, either under steady-state or inflammatory conditions, which are explored for the specific treatment of various diseases, such as cancer, autoimmunity, and transplant rejection. Here, the impact of the PE coating of ferumoxytol for uptake into both inflammatory and steady-state DCs and the cellular responses to MNP labeling is addressed. Labeling efficiency by uncoated and PE-coated ferumoxytol is highly variable in different DC subsets, and PE coating significantly improves the labeling of steady-state DCs. Uncoated ferumoxytol results in increased cytotoxicity of steady-state DCs after labeling, which is abolished by the PE coating, while no increased cell death is observed in inflammatory DCs. Furthermore, uncoated and PE-coated ferumoxytol appear immunologically inert in inflammatory DCs, but they induce activation of steady-state DCs. These results show that the PE coating of MNPs can be applied to endow particles with desired properties for enhanced uptake and cell type-specific responses in distinct target DC populations. Full article
(This article belongs to the Special Issue Nanomaterial-Based Contrast Agents for Biomedical Imaging)
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