Signaling Networks and Gene Expression in Immune Cells
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 3724
Special Issue Editors
Interests: gene expression; transcriptional regulation; macrophage activation; immunometabolism
Interests: macrophage activation; cell signaling; immunometabolism; gene expression; transcriptional regulation; mitochondria; epigenetic mechanisms
Special Issues, Collections and Topics in MDPI journals
Interests: transcriptional regulation; post-transcriptional regulation; miRNA; splicing mechanisms; liver
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immune cells fight against infections and sustain cell integrity and homeostasis by initiating and orchestrating finely tuned immune responses to manifold internal and external triggers, including pathogens and cytokines. Innate and adaptive immune responses are shaped by intricate signaling networks. In relation to this, the fascinating and rapidly evolving field of immunometabolism depicts the impact of metabolites, enzymes, and pathways on immune system plasticity in both quiescence and activation. During immune cell activation, metabolism becomes highly adaptable to promptly provide necessary materials according to the organism's requirements. Metabolic processes provide nutrients and energy and also contribute to gene expression reprogramming and transcription of multiple signal proteins. The metabolic and transcriptional profiles drive the development of various immune cell subsets. Indeed, metabolic signaling is closely related to epigenetic and, in turn, gene expression changes in both innate and adaptive immune cells. There is a large body of evidence on how aberrant immunometabolism contributes to immune dysfunction and diseases like cancer and chronic inflammatory disorders such as diabetes, obesity, atherosclerosis, and rheumatoid arthritis.
For our upcoming Special Issue, we invite researchers to contribute their valuable work, whether original research or review articles, on the most recent findings of signaling networks, including immunometabolic pathways and mechanisms of gene expression in immune cells. We further encourage contributions that delve into the regulation, mechanisms, pathways, gene expression reprogramming, cell types, and mediators involved in the interplay between immunity and metabolism, as well as emerging therapies.
Dr. Santarsiero Anna
Dr. Vittoria Infantino
Dr. Paolo Convertini
Guest Editors
Manuscript Submission Information
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Keywords
- cell signaling
- immunometabolism
- metabolic reprogramming
- immunity
- innate immune cells
- adaptive immunity
- transcriptional/post-transcriptional regulation
- gene expression
- inflammatory process
- inflammatory diseases
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