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Biomedicines
Special Issues
Deuterium Depletion: From Basic Research to Novel Therapeutic Approaches
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Deuterium Depletion: From Basic Research to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2211

Special Issue Editor

Dr. Gábor Somlyai

E-Mail Website
Guest Editor
HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary
Interests: deuterium, deuterium-depleted water, deuterium depletion, mechanism of action, anticancer drug development

Special Issue Information

Dear Colleagues,

This Special Issue, “Deuterium Depletion: From Basic Research to Novel Therapeutic Approaches”, will mainly focus on the role of deuterium and/or the deuterium/hydrogen ratio in the regulation of cell cycle, cell metabolism and about the therapeutic efficacy of deuterium depletion in a wide range of indications. The issue will focus on deuterium depletion as a new drug development strategy and its clinical implementation. Submissions proving the efficacy of deuterium depletion in other indications will also fit the scope of the Special Issue.

Deuterium depletion is an emerging field of research. Deuterium was discovered by the American chemist Harold C. Urey in 1931 (for which he was awarded the Nobel Prize for Chemistry in 1934). Due to the 100% mass difference between hydrogen (H) and deuterium (D), molecules with altered D content behave differently in chemical reactions. The possible role of deuterium in living organisms was not investigated for decades despite the fact that the D concentration is about 12–14 mmol/L in living organisms. The first paper about the regulatory role of naturally occurring deuterium in cell growth was published in 1993 (FEBS Lett. 317, 1–4). Clarifying the details of the regulatory mechanism based on changing proportions of the hydrogen–deuterium isotope pair offers a way to direct intervention into cellular processes by altering the said proportion by means of natural identical molecules. In recent years, the number of publications examining the effects of deuterium-depleted water (DDW) in different biological systems has increased across a wide array of fields, including cancer and metabolic disease research, depression, cognitive functions, and aging. The Special Issue of Biomedicines is a collection of papers centered around the basic and clinical research of deuterium depletion organized and led by subject experts.

We cordially invite authors in the field to submit original research or review articles pertaining to this important and fast-progressing field of biomedicine.

Dr. Gábor Somlyai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • deuterium
  • deuterium depletion
  • deuterium-depleted water
  • DDW
  • cell signaling
  • submolecular regulatory system
  • cell cycle
  • metabolism
  • cancer
  • aging

Published Papers (2 papers)

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Research

14 pages, 2983 KiB  
Article
Effects of Deuterium Depletion on Age-Declining Thymopoiesis In Vivo
by Nataliya V. Yaglova, Sergey S. Obernikhin, Ekaterina P. Timokhina, Dibakhan A. Tsomartova, Valentin V. Yaglov, Svetlana V. Nazimova, Elina S. Tsomartova, Marina Y. Ivanova, Elizaveta V. Chereshneva and Tatiana A. Lomanovskaya
Biomedicines 2024, 12(5), 956; https://doi.org/10.3390/biomedicines12050956 - 25 Apr 2024
Viewed by 265
Abstract
The thymus provides maturation and migration of T cells to peripheral organs of immunity, where they recognize diverse antigens and maintain immunological memory and self-tolerance. The thymus is known to be involved with age and in response to stress factors. Therefore, the search [...] Read more.
The thymus provides maturation and migration of T cells to peripheral organs of immunity, where they recognize diverse antigens and maintain immunological memory and self-tolerance. The thymus is known to be involved with age and in response to stress factors. Therefore, the search for approaches to the restoration of thymopoiesis is of great interest. The present investigation was aimed at evaluating how prolonged deuterium depletion affects morphogenetic processes and the physiological transition of the thymus to age-related involution. The study was performed on 60 male Wistar rats subjected to consumption of deuterium-depleted water with a 10 ppm deuterium content for 28 days. The control rats consumed distilled water with a normal deuterium content of 150 ppm. The examination found no significant differences in body weight gain or the amount of water consumed. The exposed rats exhibited similar to control dynamics of the thymus weight but significant changes in thymic cell maturation according to cytofluorimetric analysis of thymic subpopulations. Changes in T cell production were not monotonic and differentially engaged morphogenetic processes of cell proliferation, differentiation, and migration. The reactive response to deuterium depletion was a sharp increase in the number of progenitor CD4−CD8− cells and their differentiation into T cells. The compensatory reaction was inhibition of thymopoiesis with more pronounced suppression of differentiation of T-cytotoxic lymphocytes, followed by intensification of emigration of mature T cells to the bloodstream. This period lasts from 3 to 14 days, then differentiation of thymic lymphocytes is restored, later cell proliferation is activated, and finally the thymopoiesis rate exceeds the control values. The increase in the number of thymic progenitor cells after 3–4 weeks suggests consideration of deuterium elimination as a novel approach to prevent thymus involution. Full article
(This article belongs to the Special Issue Deuterium Depletion: From Basic Research to Novel Therapeutic Approaches)
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11 pages, 1709 KiB  
Article
A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy
by Gábor Somlyai, Beáta Zsuzsanna Kovács, András Papp and Ildikó Somlyai
Biomedicines 2023, 11(7), 1989; https://doi.org/10.3390/biomedicines11071989 - 13 Jul 2023
Viewed by 1399
Abstract
Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary malignant brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased the median survival time (MST) from 12.1 months with RT alone merely to 14.6 months, respectively. In [...] Read more.
Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary malignant brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased the median survival time (MST) from 12.1 months with RT alone merely to 14.6 months, respectively. In this study, the actions of deuterium-depleted water (DDW) on the survival of GBM patients who also received conventional therapies was investigated. Without changing the conventional treatment, the daily fluid intake of the patients was wholly replaced with DDW in 1.5–2 L per day volume to reduce the D concentration in their bodies. The primary endpoint was the MST. The 55 patients involved in this study, who received conventional treatment and consumed DDW, showed a longer MST (30 months) compared to the historical control (12.1–14.6 months). There was a massive difference between the two genders in the calculated MST values; it was 25 months in the male subgroup (n = 33) and 42 months in the female subgroup (n = 22), respectively. The MST was 27 months without TMZ treatment (38 patients) and 42 months in the TMZ-treated group (17 patients), respectively. For the selected 31 patients, who consumed DDW in the correct way in addition to their conventional treatments, their MST was calculated as 30 months. Within this group, the 20 subjects who had relapsed before DDW treatment had 30 months of MST, but in those 10 subjects who were in remission when DDW treatment started, their MST was 47 months. In the subgroup of patients who began their DDW treatment parallel with radiotherapy, their MST was again 47 months, and it was 25 months when their DDW treatment was started at 8 weeks or later after the completion of radiotherapy. Altogether, these survival times were substantially prolonged compared to the prospective clinical data of patients with primary GBM. Consequently, if conventional therapies are supplemented with D depletion, better survival can be achieved in the advanced stage of GBM than with the known targeted or combination therapies. Application of DDW is recommended in all stages of the disease before surgery and in parallel with radiotherapy, and repeated DDW courses are advised when remission has been achieved. Full article
(This article belongs to the Special Issue Deuterium Depletion: From Basic Research to Novel Therapeutic Approaches)
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