Biomedicines

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Special Issue Information

Dear Colleagues,

Non-communicable diseases (NCDs) are among the leading causes of death worldwide. NCDs comprise a large spectrum of diseases, including cardiovascular, chronic respiratory and neurological diseases, cancer, diabetes, obesity-related conditions and even infertility. Although the etiology of NCDs is as diverse as the spectrum of diseases, a growing number of studies have verified that many of these diseases share common pathophysiological mechanisms. These studies underpin that mitochondrial alterations, oxidative stress and inflammation play key roles in the onset and development of NCDs. Therefore, the pharmacological or nutritional manipulation of oxidative and inflammatory processes and targets can prevent, improve or delay the progression of NCDs, which can eventually lead to a decrease in the mortality and morbidity associated to NCDs.

This Special Issue focuses on the current understanding and future research directions regarding the role of oxidative stress and inflammation in NCDs. We warmly welcome original research, including animal research, preclinical data, as well as review articles relating to this hot topic.

Potential topics include, but are not limited to:

Identification and examination of new signaling pathways related to the onset and progression of NCDs;
Preventive and therapeutic approaches in NCDs;
The role of natural and synthetic antioxidants in modulating oxidative stress and inflammation;
Aging as a risk factor for the development of NCDs.

Dr. Renáta Szabó
Dr. Denise Börzsei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
inflammation
antioxidant therapy
aging
cardiovascular diseases
infertility
metabolic diseases
cancer

Published Papers (2 papers)

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Research

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14 pages, 2170 KiB

Open AccessArticle

Correlation of Systemic Inflammation Parameters and Serum SLFN11 in Small Cell Lung Cancer—A Prospective Pilot Study

by Ivana Simić, Azra Guzonjić, Jelena Kotur Stevuljević, Vesna Ćeriman Krstić, Natalija Samardžić, Katarina Savić Vujović and Dragana Jovanović

Biomedicines 2024, 12(5), 976; https://doi.org/10.3390/biomedicines12050976 - 29 Apr 2024

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Abstract

Background and objectives: The objective of this research was to analyze the correlation of the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), soluble programmed cell death ligand 1 (sPD-L1), and Schlafen 11 (SLFN11) with the response to first-line chemotherapy in a cohort of small cell lung cancer (SCLC) patients, and to determine their potential as predictive serum biomarkers. Materials and Methods: A total of 60 SCLC patients were included. Blood samples were taken to determine CRP, sPD-L1, and SLFN11 levels. The first sampling was performed before the start of chemotherapy, the second after two cycles, and the third after four cycles of chemotherapy. Results: The patients who died earlier during the study had NLR and SLFN11 concentrations significantly higher compared to the survivor group. In the group of survivors, after two cycles of chemotherapy, the NLR ratio decreased significantly (p < 0.01), but after four cycles, the NLR ratio increased (p < 0.05). Their serum SLFN11 concentration increased significantly (p < 0.001) after two cycles of chemotherapy, but after four cycles, the level of SLFN11 fell significantly (p < 0.01). CRP, NLR, and SLFN11 were significant predictors of patient survival according to Kaplan–Meier analysis. The combination of inflammatory parameters and SLFN11 with a cutoff value above the 75th percentile of the predicted probability was associated with significantly lower overall survival in SCLC patients (average survival of 3.6 months vs. 4.8 months). Conclusion: The combination of inflammatory markers and the levels of two specific proteins (sPD-L1, SLFN11) could potentially serve as a non-invasive biomarker for predicting responses to DNA-damaging therapeutic agents in SCLC. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation in Non-communicable Diseases)

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Review

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15 pages, 1362 KiB

Open AccessReview

Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation

by Csanád Endre Lőrincz, Denise Börzsei, Alexandra Hoffmann, Csaba Varga and Renáta Szabó

Biomedicines 2024, 12(3), 560; https://doi.org/10.3390/biomedicines12030560 - 1 Mar 2024

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Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation in Non-communicable Diseases)

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