Drug Target: Identification and Mechanism of Action

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2091

Special Issue Editor


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Guest Editor
College of Medicine, University of South Alabama, Mobile, AL, USA
Interests: nicotine; cancer cell biology; receptor signaling; GPCR; androgen receptor; dopamine D3R; MicroRNA; promoter activation

Special Issue Information

Dear Colleagues,

Drug target identification and mechanism of action (MoA) studies are essential for the development of novel drugs. The target is the molecule or cellular process that the drug will interact with to produce its desired effect. The MoA is the biochemical or cellular pathway via which the drug exerts its effect. The aims of this Special Issue are as follows:

  • Provide a forum for the latest advances in drug target identification and MoA studies.
  • Promote interdisciplinary collaboration between chemists, biologists, and medicinal chemists.
  • Highlight the importance of drug target identification and MoA studies in the development of new drugs to treat diseases.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • The mechanism of action of new and existing drugs;
  • The discovery and development of new drug targets;
  • The design and optimization of new drug molecules;
  • The use of biochemical, genetic, and cellular approaches to identify drug targets;
  • The use of computational methods to predict drug targets;
  • The study of the MoA of known drug targets;
  • The development of new methods for drug target identification and MoA studies.

Dr. Srijan Acharya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacology
  • drug discovery
  • drug targets
  • receptors function
  • target validation
  • chemical biology
  • lead optimization

Published Papers (1 paper)

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Review

17 pages, 1640 KiB  
Review
Targeting CD24 in Cancer Immunotherapy
by Wenwen Chen, Zhigang Hu and Zhigang Guo
Biomedicines 2023, 11(12), 3159; https://doi.org/10.3390/biomedicines11123159 - 27 Nov 2023
Viewed by 1464
Abstract
Immunotherapy is a hot area in cancer treatment, and one of the keys to this therapy is the identification of the right tumour-associated or tumour-specific antigen. Cluster of differentiation 24 (CD24) is an emerging tumour-associated antigen that is commonly and highly expressed in [...] Read more.
Immunotherapy is a hot area in cancer treatment, and one of the keys to this therapy is the identification of the right tumour-associated or tumour-specific antigen. Cluster of differentiation 24 (CD24) is an emerging tumour-associated antigen that is commonly and highly expressed in various tumours. In addition, CD24 is associated with several cancer-related signalling pathways and closely interacts with other molecules and immune cells to influence tumour progression. Monoclonal antibodies, antibody–drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapy, and CAR-NK cell therapy are currently available for the treatment of CD24. In this review, we summarise the existing therapeutic approaches and possible future directions targeting CD24. Full article
(This article belongs to the Special Issue Drug Target: Identification and Mechanism of Action)
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