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Biomedicines
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Connections between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and...
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Connections between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1260

Special Issue Editor

Dr. Tudoran Cristina

E-Mail Website
Guest Editor
1. Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, Timișoara, Romania
2. Department of Cardiology, County Emergency Hospital “Pius Brinzeu” Timisoara, Timișoara, Romania
Interests: heart failure; systemic hypertension; acute and chronic coronary syndrome; arrhythmias; management of patients with cardiovascular diseases; cardiovascular risk factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although the association between diabetes mellitus and other metabolic dysfunctions, such as metabolic syndrome and obesity, and cardiovascular pathologies are well known and widely studied, physicians and researchers should not underestimate the enormous impact of other endocrine dysfunctions, commencing with thyroid disorders, and also other endocrine diseases on the cardiovascular risk profile of a patient. New developments in genetics, pathophysiology, medical equipment, bioengineering, pharmacology and statistics open new horizons for the diagnosis and management of patients with various metabolic and endocrine dysfunctions, also allowing a precocious detection, even in a subclinical status of cardiovascular alterations, thus preventing their evolution to a symptomatic disease with multiple consequences for the patient.

The development of new diagnostic/therapeutic methods and protocols is needed to facilitate the precocious diagnosis and assessment of the risk profile, pre-existing cardiovascular pathologies and short- and long-term outcomes in diabetic patients, but also in those with other metabolic and endocrine dysfunctions.

This Special Issue focuses on original articles and reviews referring to groundbreaking research regarding the association between diabetes mellitus and/or other endocrine and metabolic dysfunctions and cardiovascular pathologies.

Dr. Cristina Tudoran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes mellitus
  • insulin resistance
  • metabolic syndrome
  • obesity
  • thyroid dysfunction
  • hormonal alterations
  • endothelial dysfunction
  • coronary artery disease
  • hypertension
  • peripheric arterial disease

Published Papers (2 papers)

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Research

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14 pages, 1516 KiB  
Article
The Impact of Medical Physical Training and a Structured Personalized Exercise Training Program on Hemodynamic Parameters and Arterial Stiffness in Pregnant Women
by Izabella Petre, Stela Iurciuc, Florina Buleu, Ion Petre, Radu Dumitru Moleriu, Daian Popa, Vladiana Turi, Anca Bordianu, Rabia Tasdemir, Laura Maria Craciun, Luciana Marc, Flavia Mirela Barna and Mircea Iurciuc
Biomedicines 2024, 12(5), 986; https://doi.org/10.3390/biomedicines12050986 - 30 Apr 2024
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Abstract
Introduction: In developed countries, heart disease is the primary cause of maternal mortality during pregnancy. Arterial stiffness, an independent risk factor for atherosclerosis and a predictor of cardiovascular complications, can be assessed using the augmentation index (AIx) and pulse wave velocity (PWV). In [...] Read more.
Introduction: In developed countries, heart disease is the primary cause of maternal mortality during pregnancy. Arterial stiffness, an independent risk factor for atherosclerosis and a predictor of cardiovascular complications, can be assessed using the augmentation index (AIx) and pulse wave velocity (PWV). In this prospective study, we aimed to evaluate diverse hemodynamic parameters and arterial stiffness in pregnant women before and after participating in a structured, personalized exercise training program. Materials and methods: Forty healthy pregnant women, non-smokers, who agreed to participate daily for 12 weeks in a physical exercise training program under the supervision of a team made up of an obstetrician, a cardiologist, and a physiotherapist were included. Anthropometric characteristics, arterial function, and physical activity data were collected from the participants at two different time points: at the beginning of the exercise training program (T0) and at the end, after 12 weeks (T1). Results: Upon conducting a statistical analysis, it was discovered that there were noteworthy disparities (p = 0.05) in body mass index, brachial AIx, systolic blood pressure, and pulse pressure values between the two time points. The regression analysis for the AIx brachial values and the PWVao values from Trim II (T0) and Trim III (T1) showed major differences between these two time points; the association between the AIx brachial values in the second and third trimesters of pregnancy revealed a strong direct significant correlation (p < 0.001), and the correlation between the PWVao values in the second (T0) and third trimester (T1) of pregnancy was weak and insignificant (p = 0.12). Conclusions: The findings of our study indicate that a personalized exercise training program positively impacts the physical and psychological well-being of pregnant women, leading to a reduction in PWV. Full article
(This article belongs to the Special Issue Connections between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies)
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Review

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16 pages, 365 KiB  
Review
Narrative Review of Biological Markers in Chronic Limb-Threatening Ischemia
by Alexandra Ioana Popescu, Andreea Luciana Rata, Sorin Barac, Roxana Popescu, Roxana Ramona Onofrei, Cristian Vlad and Daliborca Vlad
Biomedicines 2024, 12(4), 798; https://doi.org/10.3390/biomedicines12040798 - 3 Apr 2024
Viewed by 662
Abstract
Background: Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral arterial disease, is diagnosed in the presence of ischemic rest pain, non-healing ulcers, or gangrene. Several studies have demonstrated that inflammation and endothelial dysfunction are some of the main substrates of CLTI. Methods: [...] Read more.
Background: Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral arterial disease, is diagnosed in the presence of ischemic rest pain, non-healing ulcers, or gangrene. Several studies have demonstrated that inflammation and endothelial dysfunction are some of the main substrates of CLTI. Methods: A narrative review was conducted and reported according to PRISMA guidelines. Three databases were searched—Web of Science, Medline, and EMBASE—for the studies assessing CLTI and the biological markers related to it. Results: We included 22 studies, and all the markers identified (C-reactive protein, D-dimers, fibrinogen, cytokines, IL-6, TNF-α, ICAM-1 (Intracellular Adhesion Molecule-1), VCAM-1 (Vascular Cell Adhesion Molecule-1), neutrophile-to-lymphocytes ratio (NLR), IL-8, Pentraxin-3, neutrophil gelatinase-associated lipocalin (NGAL), calprotectin, E-selectin, P-selectin, neopterin, High-Mobility Group Box-1 protein (HGMB-1), Osteoprotegerin (OPG) and Sortilin) were positively associated with advanced CLTI, with major limb or major cardiovascular events in these patients. Conclusions: All the studied markers had increased values in patients with CLTI, especially when associated with diabetes mellitus, proving a very important association between diabetes and major limb or cardiovascular events in these patients. There is a need for more studies to validate these markers in terms of diagnosis or prognosis in CLTI patients and in trying to find new medical strategies that target inflammation or endothelial dysfunction in these patients. Full article
(This article belongs to the Special Issue Connections between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies)
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