Bioinspired Nanostructures for Innovative Functional Applications

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 6292

Special Issue Editor


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Guest Editor
Chemical Center S.r.l., Bologna, Italy
Interests: research using biomimetic, nano e biotechnologies to design characterize and produce new innovative material for ecological application

Special Issue Information

Dear Colleagues,

Nature is the supreme architect of biogenic materials. Natural materials are characterized by simplicity in their chemical composition, which is practically limited to carbonates, silicates, phosphates, halogenates, and oxides. They show a large compositional heterogeneity and have structural disorder, a low degree of crystallinity due to structural vacancies, and elementary substitution. All biogenic materials are structurally and morphologically characterized by a hierarchical assembly from nano- to macroscale. From the initial single nanometric nuclei, subsequent structural building can be a process of spontaneous self-assembly or it can be mediated by organic molecules, such as proteins and saccharides, that serve as a template. These natural nanometric particles have a high surface area and excellent chemical reactivity. Biogenic materials show high cycling stress resistance and capacity for self-repair.

If we want to synthesize new biomimetic materials, we have to employ biomimetic synthetic processes involving soft and mild conditions in water, avoiding organic solvents and toxic compounds while using self-assembly modes and macromolecular template intermediation processes.

The biomimetic approach requires the multidisciplinary involvement of chemists, physicians, biologists, geologists, naturalists and engineers, not only to try to understand Nature but also to synthesize innovative materials with the superior functionality of natural materials.

In this Special Issue, we would like to collect interdisciplinary papers that represent the efforts of research in mimicking Nature to produce innovative and functional nanostructured materials.

Prof. Dr. Norberto Roveri
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetics
  • nanostructures
  • self-assembly
  • template intermediation
  • self-repair
  • bacterial interaction
  • virus interaction
  • stress resistance
  • crystallinity
  • biomaterials
  • nanostructures

Published Papers (2 papers)

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Research

15 pages, 3187 KiB  
Article
Effects of rmBMP-7 on Osteoblastic Cells Grown on a Nanostructured Titanium Surface
by Leonardo Raphael Zuardi, Fabíola Singaretti de Oliveira, Roger Rodrigo Fernandes, Maria Paula Oliveira Gomes, Silvia Spriano, Antonio Nanci and Paulo Tambasco de Oliveira
Biomimetics 2022, 7(3), 136; https://doi.org/10.3390/biomimetics7030136 - 16 Sep 2022
Cited by 4 | Viewed by 3442
Abstract
This study evaluates the effects of the availability of exogenous BMP-7 on osteoblastic cells’ differentiation on a nanotextured Ti surface obtained by chemical etching (Nano-Ti). The MC3T3-E1 and UMR-106 osteoblastic cell lines were cultured for 5 and 7 days, respectively, on a Nano-Ti [...] Read more.
This study evaluates the effects of the availability of exogenous BMP-7 on osteoblastic cells’ differentiation on a nanotextured Ti surface obtained by chemical etching (Nano-Ti). The MC3T3-E1 and UMR-106 osteoblastic cell lines were cultured for 5 and 7 days, respectively, on a Nano-Ti surface and on a control surface (Control-Ti) in an osteogenic medium supplemented with either 40 or 200 ng/mL recombinant mouse (rm) BMP-7. The results showed that MC3T3-E1 cells exhibited distinct responsiveness when exposed to each of the two rmBMP-7 concentrations, irrespective of the surface. Even with 40 ng/mL rmBMP-7, important osteogenic effects were noticed for Control-Ti in terms of cell proliferation potential; Runx2, Osx, Alp, Bsp, Opn, and Smad1 mRNA expression; and in situ ALP activity. For Nano-Ti, the effects were limited to higher Alp, Bsp, and Opn mRNA expression and in situ ALP activity. On both surfaces, the osteogenic potential of UMR-106 cultures remained unaltered with 40 ng/mL rmBMP-7, but it was significantly reduced when the cultures were exposed to the 200 ng/mL concentration. The availability of rmBMP-7 to pre-osteoblastic cells at the concentrations used alters the expression profile of osteoblast markers, indicative of the acquisition of a more advanced stage of osteoblastic differentiation. This occurs less pronouncedly on the nanotextured Ti and without reflecting in higher mineralized matrix production by differentiated osteoblasts on both surfaces. Full article
(This article belongs to the Special Issue Bioinspired Nanostructures for Innovative Functional Applications)
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15 pages, 8327 KiB  
Article
Assessment of Optimal Conditions for Marine Invertebrate Cell-Mediated Mineralization of Organic Matrices
by Jeremy Elias, Thomas Angelini, Mark Q. Martindale and Laurie Gower
Biomimetics 2022, 7(3), 86; https://doi.org/10.3390/biomimetics7030086 - 26 Jun 2022
Viewed by 2206
Abstract
Cellular strategies and regulation of their crystallization mechanisms are essential to the formation of biominerals, and harnessing these strategies will be important for the future creation of novel non-native biominerals that recapitulate the impressive properties biominerals possess. Harnessing these biosynthetic strategies requires an [...] Read more.
Cellular strategies and regulation of their crystallization mechanisms are essential to the formation of biominerals, and harnessing these strategies will be important for the future creation of novel non-native biominerals that recapitulate the impressive properties biominerals possess. Harnessing these biosynthetic strategies requires an understanding of the interplay between insoluble organic matrices, mineral precursors, and soluble organic and inorganic additives. Our long-range goal is to use a sea anemone model system (Nematostella vectensis) to examine the role of intrinsically disordered proteins (IDPs) found in native biomineral systems. Here, we study how ambient temperatures (25–37 °C) and seawater solution compositions (varying NaCl and Mg ratios) will affect the infiltration of organic matrices with calcium carbonate mineral precursors generated through a polymer-induced liquid-precursor (PILP) process. Fibrillar collagen matrices were used to assess whether solution conditions were suitable for intrafibrillar mineralization, and SEM with EDS was used to analyze mineral infiltration. Conditions of temperatures 30 °C and above and with low Mg:Ca ratios were determined to be suitable conditions for calcium carbonate infiltration. The information obtained from these observations may be useful for the manipulation and study of cellular secreted IDPs in our quest to create novel biosynthetic materials. Full article
(This article belongs to the Special Issue Bioinspired Nanostructures for Innovative Functional Applications)
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