Chitin- and Chitosan-Based Composite Materials II

A special issue of Biomimetics (ISSN 2313-7673).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 2997

Special Issue Editors


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Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid (UCM), 28040 Madrid, Spain
Interests: polymer chemistry; natural polymers; green processes; metallic nanoparticles; drug delivery; antimicrobial; polimeric matrix; biomaterials; composites
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: biopolymers; chitosan derivatives; physico-chemical and functional characterization; green processes; polymer networks; biomaterials; drug delivery; pharmaceutical formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitin and its deacetylated derivative, chitosan, are a family of copolymers composed of poly β-1,4 linked D-glucosamine and N-acetyl-D-glucosamine. These polymers exhibit a large number of biological (non-toxicity, bioactivity, biocompatibility and biodegradability among others) and technological properties that are of interest in different fields, such as biomedicine, agriculture, biotechnology or the textile industry. Moreover, chitin, chitosan and their derivatives can be processed into different forms such as micro- and nanoparticles, fibers, films or scaffolds. These structures are compatible with other types of materials like metallic or magnetic nanoparticles, and carbonous or inorganic materials. Therefore, a myriad of composites based on chitinous materials can be easily produced with interesting properties.

This Special Issue aims to collect the contributions from researchers from different fields with a common interest in chitin- and chitosan-based materials. Due to the strong relationship between polymer physico-chemical properties and functional behavior, researchers are encouraged to include detailed methods for polymer characterization.

Dr. Inmaculada Aranaz Corral
Dr. Florentina Niuris Acosta Contreras
Guest Editors

Manuscript Submission Information

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Keywords

  • metallic nanoparticles
  • magnetic nanoparticles
  • carbon nanofibers
  • carbon nanotubes
  • hydroxyapatite
  • bioglass
  • drug delivery
  • clays
  • bioplastics

Published Papers (1 paper)

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Research

16 pages, 7586 KiB  
Article
Optimization by Central Composite Experimental Design of the Synthesis of Physically Crosslinked Chitosan Spheres
by Sara Isabel Zamora Lagos, Jefferson Murillo Salas, Mayra Eliana Valencia Zapata, José Herminsul Mina Hernández and Carlos David Grande Tovar
Biomimetics 2020, 5(4), 63; https://doi.org/10.3390/biomimetics5040063 - 20 Nov 2020
Cited by 2 | Viewed by 2493
Abstract
Chitosan (CS) has special properties such as biocompatibility, biodegradability, antibacterial, and biological activity which make this material is currently studied in various applications, including tissue engineering. There are different methods to modify the morphology of CS. Most use chemical crosslinking agents, however, those [...] Read more.
Chitosan (CS) has special properties such as biocompatibility, biodegradability, antibacterial, and biological activity which make this material is currently studied in various applications, including tissue engineering. There are different methods to modify the morphology of CS. Most use chemical crosslinking agents, however, those methods have disadvantages such as low polymer degradability and unwanted side effects. The objective of this research was to obtain CS spheres through the physical crosslinking of commercial CS without using crosslinking agents through a simple coacervation method. A central composite experimental design was used to optimize the synthesis of the CS spheres and by the response surface methodology it was possible to obtain CS spheres with the smallest diameter and the most regular morphology. With the optimal formulation (CS solution 1.8% (w/v), acetic acid (AAC) solution 1% (w/v), sodium hydroxide (NaOH) solution 13% (w/v), relative humidity of (10%) and needle diameter of 0.6 mm), a final sphere diameter of 1 mm was obtained. Spheres were characterized by physical, chemical, thermal, and biological properties in simulated body fluid (SBF). The results obtained allowed us to understand the effect of the studied variables on the spheres’ diameter. An optimized condition facilitated the change in the morphology of the CS while maintaining its desirable properties for use in tissue engineering. Full article
(This article belongs to the Special Issue Chitin- and Chitosan-Based Composite Materials II)
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