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Journals
Biomolecules
Special Issues
Biomarkers in Oral Diseases 2.0
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Biomarkers in Oral Diseases 2.0

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 6102

Special Issue Editors

Dr. Giuseppe Pannone

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 70121 Foggia, Italy
Interests: head and neck oncology; head and neck squamous cell carcinoma; head and neck pathology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fernanda Visioli

E-Mail Website
Guest Editor
Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Interests: squamous cell carcinoma of head and neck; carcinogenesis; chemoprevention

Special Issue Information

Dear Colleagues,

Oral diseases comprise a very heterogeneous group of pathologies, from inflammatory to neoplastic process, including oral manifestations from systemic diseases. The characterization of novel biomarkers to identify disease onset, progression, and prognosis is extremely valuable to improve diagnosis competence as well to improve treatment choice and efficiency. Validated biomarkers are primal for an optimized personalized patient care.

The aim of this Special Issue entitled “Biomarkers in Oral Diseases 2.0” is to encourage clinicians, specialists, and researchers to share their findings regarding molecular, cellular, histological, serological, salivary, and cellular matrix biomarkers/biomolecules of oral mucosae and teeth diseases, including oral, periodontal, and peri-implant tissues. From tooth decay to periodontal/peri-implant diseases, from oral potentially malignant disorders to oral squamous cell carcinoma with an eye on systemic diseases with oral manifestation, we encourage authors to submit both original articles and literature reviews regarding biomarkers in oral diseases. Original research and reviews highlighting an immediate diagnostic/therapeutic/clinical impact of the investigated biomarker(s) will be considered of particular interest.

We look forward to your contribution.

Dr. Giuseppe Pannone
Prof. Dr. Fernanda Visioli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cancer
  • oral carcinogenesis
  • oral potentially malignant disorders
  • oral manifestations of autoimmune mediated diseases
  • periodontal diseases
  • head and neck pathology

Published Papers (3 papers)

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Research

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18 pages, 27277 KiB  
Article
Depletion of PHLDB2 Suppresses Epithelial–Mesenchymal Transition and Enhances Anti-Tumor Immunity in Head and Neck Squamous Cell Carcinoma
by Hongyu Li, Ziyi Wang, Huiting Liang, Xiaoyong Liu, Haichao Liu, Zehang Zhuang and Jinsong Hou
Biomolecules 2024, 14(2), 232; https://doi.org/10.3390/biom14020232 - 17 Feb 2024
Viewed by 922
Abstract
The role of Pleckstrin homology-like domain family B member 2 (PHLDB2) in the regulation of cell migration has been extensively studied. However, the exploration of PHLDB2 in head and neck squamous cell carcinoma (HNSCC) is still limited in terms of expression, function, and [...] Read more.
The role of Pleckstrin homology-like domain family B member 2 (PHLDB2) in the regulation of cell migration has been extensively studied. However, the exploration of PHLDB2 in head and neck squamous cell carcinoma (HNSCC) is still limited in terms of expression, function, and therapeutic potential. In this study, we discovered an upregulation of PHLDB2 expression in HNSCC tissues which was correlated with a negative prognosis in patients with HNSCC. Additionally, we determined that a high level of expression of PHLDB2 is crucial for maintaining cell migration through the regulation of the epithelial–mesenchymal transition (EMT). Furthermore, we demonstrated that the ablation of PHLDB2 in tumor cells inhibited tumorigenicity in a C3H syngeneic tumor-bearing mouse model. Mechanistically, PHLDB2 was found to be involved in the regulation of T cell anti-tumor immunity, primarily by enhancing the activation and infiltration of CD8+ T cells. In light of these findings, PHLDB2 emerges as a promising biomarker and therapeutic target for interventions in HNSCC. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases 2.0)
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10 pages, 1924 KiB  
Article
Bacterial and Cellular Response to Yellow-Shaded Surface Modifications for Dental Implant Abutments
by Tullio Genova, Giorgia Chinigò, Luca Munaron, Paola Rivolo, Anna Luganini, Giorgio Gribaudo, Davide Cavagnetto, Pietro Mandracci and Federico Mussano
Biomolecules 2022, 12(11), 1718; https://doi.org/10.3390/biom12111718 - 20 Nov 2022
Cited by 1 | Viewed by 1551
Abstract
Dental implants have dramatically changed the rehabilitation procedures in dental prostheses but are hindered by the possible onset of peri-implantitis. This paper aims to assess whether an anodization process applied to clinically used surfaces could enhance the adhesion of fibroblasts and reduce bacterial [...] Read more.
Dental implants have dramatically changed the rehabilitation procedures in dental prostheses but are hindered by the possible onset of peri-implantitis. This paper aims to assess whether an anodization process applied to clinically used surfaces could enhance the adhesion of fibroblasts and reduce bacterial adhesion using as a reference the untreated machined surface. To this purpose, four different surfaces were prepared: (i) machined (MAC), (ii) machined and anodized (Y-MAC), (iii) anodized after sand-blasting and acid etching treatment (Y-SL), and (iv) anodized after double acid etching (Y-DM). All specimens were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Moreover, the mean contact angle in both water and diiodomethane as well as surface free energy calculation was assessed. To evaluate changes in terms of biological responses, we investigated the adhesion of Streptococcus sanguinis (S. sanguinis) and Enterococcus faecalis (E. faecalis), fetal bovine serum (FBS) adsorption, and the early response of fibroblasts in terms of cell adhesion and viability. We found that the anodization reduced bacterial adhesion, while roughened surfaces outperformed the machined ones for protein adsorption, fibroblast adhesion, and viability independently of the treatment. It can be concluded that surface modification techniques such as anodization are valuable options to enhance the performance of dental implants. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases 2.0)
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Review

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18 pages, 721 KiB  
Review
The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach
by Anna Smędra and Jarosław Berent
Biomolecules 2023, 13(5), 815; https://doi.org/10.3390/biom13050815 - 11 May 2023
Cited by 2 | Viewed by 2911
Abstract
In our recent article (Smędra et al.: Oral form of auto-brewery syndrome. J Forensic Leg Med. 2022; 87: 102333), we showed that alcohol production can occur in the oral cavity (oral auto-brewery syndrome) due to a disruption in the microbiota (dysbiosis). An intermediate [...] Read more.
In our recent article (Smędra et al.: Oral form of auto-brewery syndrome. J Forensic Leg Med. 2022; 87: 102333), we showed that alcohol production can occur in the oral cavity (oral auto-brewery syndrome) due to a disruption in the microbiota (dysbiosis). An intermediate step on the path leading to the formation of alcohol is acetaldehyde. Typically, acetic aldehyde is transformed into acetate particles inside the human body via acetaldehyde dehydrogenase. Unfortunately, acetaldehyde dehydrogenase activity is low in the oral cavity, and acetaldehyde remains there for a long time. Since acetaldehyde is a recognised risk factor for squamous cell carcinoma arising from the oral cavity, we decided to analyse the relationship linking the oral microbiome, alcohol, and oral cancer using the narrative review method, based on browsing articles in the PubMed database. In conclusion, enough evidence supports the speculation that oral alcohol metabolism must be assessed as an independent carcinogenic risk. We also hypothesise that dysbiosis and the production of acetaldehyde from non-alcoholic food and drinks should be treated as a new factor for the development of cancer. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases 2.0)
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