Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.1
3.7
Journals
Pathogens
Special Issues
Biomarkers in Oral Diseases
share announcement

Biomarkers in Oral Diseases

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 6874

Special Issue Editors

Dr. Agostino Guida

E-Mail Website
Guest Editor
U.O.C. di Odontostomatologia, “AORN A. Cardarelli” Hospital, Via A. Cardarelli, 80131 Naples, Italy
Interests: oral potentially malignant disorders; oral squamous cell carcinoma; oral surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Pannone

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 70121 Foggia, Italy
Interests: head and neck oncology; head and neck squamous cell carcinoma; head and neck pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Annunziata

E-Mail Website
Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: periodontal diseases; implant dentistry; peri-implant diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As emerging from recent scientific literature, the identification of novel molecular biomarkers represents a most innovative and effective approach to both diagnosis and therapy. The stratification of patients through the investigation of variations in local/systemic levels of biomolecules may lead to the individualization of the whole pathway of care. Healthcare professionals—both clinicians and researchers—dedicated to oral health have taken up the challenge, in order to fill in the gaps with other medical specialties where individualized therapy is already a consolidated reality. For breast cancer and melanoma, genetic typing of the tumor/patient has led to the dramatic improvement of early diagnosis and the identification of therapeutic targets, effectively influencing prognosis and survival.

Diseases affecting the oral cavity are extremely heterogeneous, involving different medical specialists committed to both clinical and research activities. The aim of this Special Issue entitled “Biomarkers in Oral Diseases” is to encourage clinicians and basic researchers to share their findings regarding intracellular, histological, hematological, and cellular matrix biomarkers/biomolecules of teeth and mucosae, including oral, periodontal, and peri-implant tissues. From tooth decay to periodontal/peri-implant diseases, from oral potentially malignant disorders to oral squamous cell carcinoma with an eye on systemic diseases with oral manifestation, we encourage authors to submit both original articles and literature reviews regarding biomarkers in oral diseases. Articles/reviews highlighting an immediate diagnostic/therapeutic/clinical impact of the investigated biomarker(s) will be considered of particular interest.

We look forward to your contribution.

You may choose our Joint Special Issue in Biomolecules.

Dr. Agostino Guida
Prof. Dr. Giuseppe Pannone
Prof. Dr. Marco Annunziata
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral potentially malignant disorders
  • oral squamous cell carcinoma
  • periodontal diseases
  • peri-implant diseases
  • head and neck pathology

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 1607 KiB  
Article
Salivary miR-31-5p, miR-345-3p, and miR-424-3p Are Reliable Biomarkers in Patients with Oral Squamous Cell Carcinoma
by Beáta Scholtz, József Horváth, Ildikó Tar, Csongor Kiss and Ildikó J. Márton
Pathogens 2022, 11(2), 229; https://doi.org/10.3390/pathogens11020229 - 09 Feb 2022
Cited by 15 | Viewed by 2180
Abstract
If not detected early, oral squamous cell carcinoma (OSCC) has very poor prognosis, emphasizing the need for reliable early diagnostics. Saliva is considered a promising surrogate biosample for OSCC detection, because it comes into contact with many cells of the tumor mass, providing [...] Read more.
If not detected early, oral squamous cell carcinoma (OSCC) has very poor prognosis, emphasizing the need for reliable early diagnostics. Saliva is considered a promising surrogate biosample for OSCC detection, because it comes into contact with many cells of the tumor mass, providing a comprehensive sampling of tumor-specific biomolecules. Although several protein- and RNA-based salivary biomarkers have been proposed for the detection of OSCC, the results of the studies show large differences. Our goal was to clarify which salivary microRNAs (miRNA) show reliably high expression in the saliva of OSCC patients, to be used as cancer-specific biomarkers, and potentially as early diagnostic biomarkers. Based on a detailed literature search, we selected six miRNAs commonly overexpressed in OSCC, and analyzed their expression in saliva samples of cancer patients and controls by real-time quantitative PCR. Our results suggest that miR-345 and miR-31-5p are consistently upregulated salivary biomarkers for OSCC, and a three-miRNA panel of miR-345, miR-31-5p, and miR-424-3p can distinguish cancer and control patients with high sensitivity. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases)
►▼ Show Figures

Figure 1

10 pages, 587 KiB  
Article
Evaluation of the Expression of miR-486-3p, miR-548-3p, miR-561-5p and miR-509-5p in Tumor Biopsies of Patients with Oral Squamous Cell Carcinoma
by Ata Garajei, Milad Parvin, Hady Mohammadi, Abdolamir Allameh, Azin Hamidavi, Masoud Sadeghi, Azadeh Emami and Serge Brand
Pathogens 2022, 11(2), 211; https://doi.org/10.3390/pathogens11020211 - 05 Feb 2022
Cited by 8 | Viewed by 1585
Abstract
Background and objective: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Expression patterns of microRNAs (miRNAs) can direct us in identifying valuable biomarkers for the prognosis of different neoplasms. Inappropriate regulation of miRNAs during physiological procedures can result [...] Read more.
Background and objective: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Expression patterns of microRNAs (miRNAs) can direct us in identifying valuable biomarkers for the prognosis of different neoplasms. Inappropriate regulation of miRNAs during physiological procedures can result in malignancies including OSCC. The aim of the present study was to evaluate the expression of miR-486-3p, miR-561-5p, miR-548-3p, and miR-509-5p in tissue biopsy samples with and without OSCC. Materials and methods: This case-control study was conducted on 17 healthy and 17 OSCC tissue biopsy samples. The expression of miRNAs was assessed using quantitative real-time PCR (q-RT-PCR) after RNA extraction from normal and cancer tissues and cDNA synthesis. Results: The means of miRNA-486-3p, miR-561-5p, and miR-548-3p expression were significantly different between OSCC and control groups (p < 0.001), but there was no significant difference in means of miR-509-5p expression between OSCC and control groups (p = 0.179). Conclusions: The findings of this study revealed that the expression of miR-486-3p and miR-561-5p was significantly lower in cancer samples compared to normal tissue samples. On the other hand, miR-548-3p expression increased in the OSCC group compared to the control group. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

21 pages, 873 KiB  
Review
Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis
by Hady Mohammadi, Mehrnoush Momeni Roochi, Masoud Sadeghi, Ata Garajei, Hosein Heidar, Ali Aghaie Meybodi, Mohsen Dallband, Sarton Mostafavi, Melina Mostafavi, Mojtaba Salehi, Jyothi Tadakamadla, Dena Sadeghi-Bahmani and Serge Brand
Pathogens 2021, 10(12), 1600; https://doi.org/10.3390/pathogens10121600 - 09 Dec 2021
Cited by 7 | Viewed by 2355
Abstract
Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We [...] Read more.
Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between IL−1 polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between IL−1A (–889), IL−1B (−511), IL−1B (+3953), and IL−1RN (VNTR) polymorphisms and the risk of dental PIDs, but there was an increased risk of IL−1B (+3954) in the patients with PIDs. In addition, an association of the composite genotype of IL−1A (−889)/IL−1B (+3953) was observed with the risk of PIDs, but not for the composite genotype of IL−1A (−889)/IL−1B (+3954). The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. Conclusions: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of IL−1A (−889)/IL−1B (+3953) and IL−1B (+3954) were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of IL−1B (+3954) polymorphism were also associated with an elevated risk of PID. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop